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Structural dynamics of nucleosome core particles upon DNA methylation and MeCP2 binding

Structural dynamics of nucleosome core particles upon DNA methylation and MeCP2 binding
DNA甲基化和MeCP2结合时核小体核心颗粒的结构动力学
批准号：
441129
负责人：
Bolik-Coulon Nicolas
金额：
$9.83万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441129&lang=en
关键词：
Dna Methylation Dna-Protein Interactions Electron Cryo-Microscopy Mecp2 Methyl-Trosy Neurodegenerative Diseases Nuclear Magnetic Resonance Nucleosome Protein And Dna Dynamics

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英文摘要
In humans DNA is organized into basic units in which it is wrapped around a protein core to form a structure called a nucleosome core particle (NCP). NCPs are subject to a variety of chemical modifications, affecting both their DNA and protein components,
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