Polymer-encapsulated copper-based nanoparticles: synthesis and evaluation of surface coatings for reduction of COVID-19 transmission

聚合物封装的铜基纳米颗粒：用于减少 COVID-19 传播的表面涂层的合成和评估

• 批准号: 554497-2020
• 负责人: Goh, MCynthia
• 金额: $ 3.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705666
• 关键词: Polymer; encapsulated; copper; based; nanoparticles

Corona viruses can be transmitted by contamination of dry surfaces where they can persist for hours to days depending on the surface material. Cleaning high touch surfaces, such as doorknobs and elevator buttons, are key elements in the fight against infection. Our goal is to help reduce transmission of the disease by providing a coating that will continuously disinfect the surface in-between regular cleaning. Copper is a long known antimicrobial, and it has been reported that SARS-CoV 2 persists for less time on copper than on other surfaces. However, not everything can be made of copper. Our approach is to focus on copper-based nanoparticles suspended in water, to be used as a spray coating, effectively providing a source of copper for disinfection. In this project, we will investigate various copper-based polymer-encapsulated nanoparticles that will be made using our approach based on counter-ion polymer collapse. We will synthesize nanoparticles made of copper, copper alloys and copper compounds. These materials will be tested for their action on E. coli, which will serve as a model system for SARS-CoV 2. A coating formulation incorporating the various nanoparticles will then be created. Plastic and glass surfaces will be coated, and tested for their ability to inactivate E. coli. Our partner Vive Crop Protection has expertise in nanomaterials synthesis and formulation, and has experience with copper in its application to agriculture. They will provide assistance with the technology as well as an industrial perspective and knowledge of the regulatory issues to enable this potential product to enter the market.

冠状病毒可通过干燥表面的污染传播，根据表面材料的不同，它们可以持续数小时至数天。清洁高接触表面，如门把手和电梯按钮，是对抗感染的关键因素。我们的目标是通过提供一种涂层来帮助减少疾病的传播，这种涂层可以在定期清洁之间持续消毒表面。