Finding innovations to improve calf gastrointestinal health
寻找改善犊牛胃肠道健康的创新
基本信息
- 批准号:558264-2020
- 负责人:
- 金额:$ 4.88万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Alliance Grants
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Canadian dairy industry is one of the largest agricultural sectors in the country, contributing almost 20
billion dollars to the GDP every year. Despite this rapid growth, dairy calves continue to suffer from high rates
of morbidity and mortality, with digestive disorders accounting for over half of reported illnesses and one-third
of deaths. Several factors embedded within current management practices pose challenges to animal gut
health, compromising their tract barrier function, normally referred to as "leaky gut". Studying the contributing
factors of leaky gut is difficult because the conditions responsible for reducing intestinal barrier integrity can
also affect the metabolism of other tissues. Probiotics promote gut mucosal health by limiting pathogen
invasion and providing a stable, nutrient-rich environment for gut microbiota, thereby enhancing host digestive
efficiency and immune function. Lactobacillus helveticus (LH) supplementation has been shown to
improve gut barrier function through modulation of gut immune function. However, no studies have evaluated
the effects of LH on barrier function, inflammation, and gut health in ruminants during preweaning and
postweaning. Furthermore, there is currently limited information regarding models to study leaky gut in
isolation. Previous research has unsuccessfully attempted to create models to induce leaky gut and has focused
solely on the systemic inflammatory response without directly assessing gut permeability. Therefore, this
proposal aims to improve our understanding of how this digestive disorder impacts host physiology and animal
performance. This research encompasses the development of a model to better understand the aetiology of
leaky gut and the models generated will serve to evaluate the impact of LH supplementation on
barrier function, inflammatory response and energy metabolism.
加拿大乳制品行业是该国最大的农业部门之一,贡献了近20
10亿美元的GDP。尽管这种快速增长,奶牛小牛继续遭受高利率
消化系统疾病占报告疾病的一半以上,
死亡。当前管理实践中的几个因素对动物肠道构成了挑战
健康,损害他们的肠道屏障功能,通常被称为“漏肠”。研究贡献
肠漏的因素是困难的,因为负责降低肠屏障完整性的条件可以
也会影响其他组织的新陈代谢。益生菌通过限制病原体促进肠道粘膜健康
入侵和提供一个稳定的,营养丰富的环境,肠道微生物群,从而提高宿主消化
效率和免疫功能。瑞士乳杆菌(LH)补充剂已被证明
通过调节肠道免疫功能改善肠道屏障功能。然而,没有研究评估
LH对断奶前反刍动物屏障功能、炎症和肠道健康的影响,
断奶后此外,目前关于研究肠漏的模型的信息有限,
隔离以前的研究没有成功地尝试建立模型来诱导肠漏,
仅对全身炎症反应进行评估,而不直接评估肠道通透性。因此本
该提案旨在提高我们对这种消化障碍如何影响宿主生理和动物的理解
性能这项研究包括一个模型的发展,以更好地了解病因,
漏肠和产生的模型将用于评估LH补充对
屏障功能、炎症反应和能量代谢。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steele, Michael其他文献
Translation and piloting of the Chinese Mandarin version of an intensive care-specific pressure injury risk assessment tool (the COMHON Index).
- DOI:
10.1016/j.ijnss.2022.03.003 - 发表时间:
2022-04 - 期刊:
- 影响因子:3.8
- 作者:
Lovegrove, Josephine;Fulbrook, Paul;Miles, Sandra J.;Steele, Michael;Liu, Xian-Liang;Zhang, Lin;Cobos Vargas, Angel - 通讯作者:
Cobos Vargas, Angel
Loitering of the retreating sea ice edge in the Arctic Seas.
- DOI:
10.1002/2015jc011182 - 发表时间:
2015-12 - 期刊:
- 影响因子:3.6
- 作者:
Steele, Michael;Ermold, Wendy - 通讯作者:
Ermold, Wendy
Accelerated sea ice loss in the Wandel Sea points to a change in the Arctic’s Last Ice Area
万德尔海海冰加速流失表明北极最后的冰区发生了变化
- DOI:
10.1038/s43247-021-00197-5 - 发表时间:
2021 - 期刊:
- 影响因子:7.9
- 作者:
Schweiger, Axel J.;Steele, Michael;Zhang, Jinlun;Moore, G. W. K.;Laidre, Kristin L. - 通讯作者:
Laidre, Kristin L.
Seasonal heat and freshwater cycles in the Arctic Ocean in CMIP5 coupled models
CMIP5 耦合模型中北冰洋的季节性热量和淡水循环
- DOI:
10.1002/2015jc011124 - 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Ding, Yanni;Carton, James A.;Chepurin, Gennady A.;Steele, Michael;Hakkinen, Sirpa - 通讯作者:
Hakkinen, Sirpa
Analysis of the Arctic System for Freshwater Cycle Intensification: Observations and Expectations
- DOI:
10.1175/2010jcli3421.1 - 发表时间:
2010-11-01 - 期刊:
- 影响因子:4.9
- 作者:
Rawlins, Michael A.;Steele, Michael;Zhang, Tingjun - 通讯作者:
Zhang, Tingjun
Steele, Michael的其他文献
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{{ truncateString('Steele, Michael', 18)}}的其他基金
Maternal and Lactocrine Programming of the Neonatal Gut
新生儿肠道的母体和泌乳编程
- 批准号:
RGPIN-2022-04389 - 财政年份:2022
- 资助金额:
$ 4.88万 - 项目类别:
Discovery Grants Program - Individual
The unexplored bioactivity of colostrum
初乳的未开发生物活性
- 批准号:
556284-2020 - 财政年份:2021
- 资助金额:
$ 4.88万 - 项目类别:
Alliance Grants
Regulation of Gastrointestinal Growth and Function
胃肠道生长和功能的调节
- 批准号:
RGPIN-2016-05543 - 财政年份:2021
- 资助金额:
$ 4.88万 - 项目类别:
Discovery Grants Program - Individual
Finding innovations to improve calf gastrointestinal health
寻找改善犊牛胃肠道健康的创新
- 批准号:
558264-2020 - 财政年份:2021
- 资助金额:
$ 4.88万 - 项目类别:
Alliance Grants
Finding solutions to alleviate gastrointestinal health in dairy cows and calves
寻找缓解奶牛和犊牛胃肠健康的解决方案
- 批准号:
570914-2021 - 财政年份:2021
- 资助金额:
$ 4.88万 - 项目类别:
Alliance Grants
The impact of prepartum energy intake on colostrum quality and calf performance
产前能量摄入对初乳质量和犊牛生产性能的影响
- 批准号:
561532-2021 - 财政年份:2021
- 资助金额:
$ 4.88万 - 项目类别:
Alliance Grants
NSERC Industrial Research Chair in Dairy Nutrition
NSERC 乳制品营养工业研究主席
- 批准号:
499136-2015 - 财政年份:2020
- 资助金额:
$ 4.88万 - 项目类别:
Industrial Research Chairs
Regulation of Gastrointestinal Growth and Function
胃肠道生长和功能的调节
- 批准号:
RGPIN-2016-05543 - 财政年份:2020
- 资助金额:
$ 4.88万 - 项目类别:
Discovery Grants Program - Individual
Colostrum - more than immunoglobulins
初乳 - 不仅仅是免疫球蛋白
- 批准号:
543915-2019 - 财政年份:2020
- 资助金额:
$ 4.88万 - 项目类别:
Collaborative Research and Development Grants
The unexplored bioactivity of colostrum
初乳的未开发生物活性
- 批准号:
556284-2020 - 财政年份:2020
- 资助金额:
$ 4.88万 - 项目类别:
Alliance Grants
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- 批准号:
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- 资助金额:
$ 4.88万 - 项目类别:
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