Finding innovations to improve calf gastrointestinal health

加拿大乳制品行业是该国最大的农业部门之一，贡献了近20 10亿美元的GDP。尽管这种快速增长，奶牛小牛继续遭受高利率 消化系统疾病占报告疾病的一半以上， 死亡当前管理实践中的几个因素对动物肠道构成了挑战 健康，损害他们的肠道屏障功能，通常被称为“漏肠”。研究贡献 肠漏的因素是困难的，因为负责降低肠屏障完整性的条件可以 也会影响其他组织的新陈代谢。益生菌通过限制病原体促进肠道粘膜健康 入侵和提供一个稳定的，营养丰富的环境，肠道微生物群，从而提高宿主消化 效率和免疫功能。瑞士乳杆菌（LH）补充剂已被证明 通过调节肠道免疫功能改善肠道屏障功能。然而，没有研究评估 LH对断奶前反刍动物屏障功能、炎症和肠道健康的影响， 断奶后此外，目前关于研究肠漏的模型的信息有限， 隔离以前的研究没有成功地尝试建立模型来诱导肠漏， 仅对全身炎症反应进行评估，而不直接评估肠道通透性。因此本 该提案旨在提高我们对这种消化障碍如何影响宿主生理和动物的理解 性能这项研究包括一个模型的发展，以更好地了解病因， 漏肠和产生的模型将用于评估LH补充对 屏障功能、炎症反应和能量代谢。

The Canadian dairy industry is one of the largest agricultural sectors in the country, contributing almost 20 billion dollars to the GDP every year. Despite this rapid growth, dairy calves continue to suffer from high rates of morbidity and mortality, with digestive disorders accounting for over half of reported illnesses and one-third of deaths. Several factors embedded within current management practices pose challenges to animal gut health, compromising their tract barrier function, normally referred to as "leaky gut". Studying the contributing factors of leaky gut is difficult because the conditions responsible for reducing intestinal barrier integrity can also affect the metabolism of other tissues. Probiotics promote gut mucosal health by limiting pathogen invasion and providing a stable, nutrient-rich environment for gut microbiota, thereby enhancing host digestive efficiency and immune function. Lactobacillus helveticus (LH) supplementation has been shown to improve gut barrier function through modulation of gut immune function. However, no studies have evaluated the effects of LH on barrier function, inflammation, and gut health in ruminants during preweaning and postweaning. Furthermore, there is currently limited information regarding models to study leaky gut in isolation. Previous research has unsuccessfully attempted to create models to induce leaky gut and has focused solely on the systemic inflammatory response without directly assessing gut permeability. Therefore, this proposal aims to improve our understanding of how this digestive disorder impacts host physiology and animal performance. This research encompasses the development of a model to better understand the aetiology of leaky gut and the models generated will serve to evaluate the impact of LH supplementation on barrier function, inflammatory response and energy metabolism.