Finding innovations to improve calf gastrointestinal health

加拿大乳制品业是该国最大的农业部门之一，贡献了近 20 每年GDP 达亿美元。尽管增长迅速，但奶牛犊的发病率仍居高不下 发病率和死亡率，消化系统疾病占报告疾病的一半以上，三分之一以上 死亡人数。当前管理实践中的几个因素对动物肠道提出了挑战 健康，损害肠道屏障功能，通常称为“肠漏”。研究贡献 肠漏的因素很困难，因为导致肠道屏障完整性降低的条件可以 也影响其他组织的新陈代谢。益生菌通过限制病原体促进肠道粘膜健康 入侵并为肠道微生物群提供稳定、营养丰富的环境，从而增强宿主消化 效率和免疫功能。瑞士乳杆菌 (LH) 补充剂已被证明可以 通过调节肠道免疫功能来改善肠道屏障功能。然而，没有研究评估 LH 对断奶前和断奶期间反刍动物屏障功能、炎症和肠道健康的影响 断奶后。此外，目前有关研究肠漏的模型的信息有限。 隔离。先前的研究曾尝试创建诱导肠漏的模型，但未成功，并且重点关注 仅关注全身炎症反应，而不直接评估肠道通透性。因此，这 该提案旨在提高我们对这种消化疾病如何影响宿主生理和动物的理解 性能。这项研究包括开发一个模型，以更好地了解疾病的病因学 肠漏症和生成的模型将用于评估 LH 补充剂对 屏障功能、炎症反应和能量代谢。

The Canadian dairy industry is one of the largest agricultural sectors in the country, contributing almost 20 billion dollars to the GDP every year. Despite this rapid growth, dairy calves continue to suffer from high rates of morbidity and mortality, with digestive disorders accounting for over half of reported illnesses and one-third of deaths. Several factors embedded within current management practices pose challenges to animal gut health, compromising their tract barrier function, normally referred to as "leaky gut". Studying the contributing factors of leaky gut is difficult because the conditions responsible for reducing intestinal barrier integrity can also affect the metabolism of other tissues. Probiotics promote gut mucosal health by limiting pathogen invasion and providing a stable, nutrient-rich environment for gut microbiota, thereby enhancing host digestive efficiency and immune function. Lactobacillus helveticus (LH) supplementation has been shown to improve gut barrier function through modulation of gut immune function. However, no studies have evaluated the effects of LH on barrier function, inflammation, and gut health in ruminants during preweaning and postweaning. Furthermore, there is currently limited information regarding models to study leaky gut in isolation. Previous research has unsuccessfully attempted to create models to induce leaky gut and has focused solely on the systemic inflammatory response without directly assessing gut permeability. Therefore, this proposal aims to improve our understanding of how this digestive disorder impacts host physiology and animal performance. This research encompasses the development of a model to better understand the aetiology of leaky gut and the models generated will serve to evaluate the impact of LH supplementation on barrier function, inflammatory response and energy metabolism.