Finding innovations to improve calf gastrointestinal health

加拿大奶业是该国最大的农业部门之一，贡献了近20%的 每年为国内生产总值贡献10亿美元。尽管增长速度很快，但产奶牛犊的产奶率仍然很高。 发病率和死亡率，消化系统疾病占报告疾病的一半以上，三分之一 死亡的威胁。当前管理实践中的几个因素对动物肠道构成了挑战 健康，损害他们的肠道屏障功能，通常被称为“渗漏肠道”。研究贡献者 肠漏的因素是困难的，因为导致肠道屏障完整性降低的条件可能 也会影响其他组织的新陈代谢。益生菌通过限制病原体促进肠道粘膜健康 入侵并为肠道微生物群提供稳定的、营养丰富的环境，从而增强宿主的消化能力 效率和免疫功能。瑞士乳杆菌(Lactobacillushelveticus)的补充已被证明 通过调节肠道免疫功能，改善肠道屏障功能。然而，还没有研究评估 促黄体生成素对断奶前和断奶后反刍动物屏障功能、炎症和肠道健康的影响 断奶后。此外，目前关于用于研究肠道渗漏的模型的信息有限。 与世隔绝。以前的研究试图建立模型来诱导肠漏，但没有成功，并将重点放在了 仅依赖于全身炎症反应，而不直接评估肠道通透性。因此，这 该提案旨在提高我们对这种消化障碍如何影响宿主生理和动物的理解 性能。这项研究包括开发一种模型，以更好地理解肺炎的病因 漏肠和所生成的模型将用于评估补充黄体生成素对 屏障功能、炎症反应和能量代谢。

The Canadian dairy industry is one of the largest agricultural sectors in the country, contributing almost 20 billion dollars to the GDP every year. Despite this rapid growth, dairy calves continue to suffer from high rates of morbidity and mortality, with digestive disorders accounting for over half of reported illnesses and one-third of deaths. Several factors embedded within current management practices pose challenges to animal gut health, compromising their tract barrier function, normally referred to as "leaky gut". Studying the contributing factors of leaky gut is difficult because the conditions responsible for reducing intestinal barrier integrity can also affect the metabolism of other tissues. Probiotics promote gut mucosal health by limiting pathogen invasion and providing a stable, nutrient-rich environment for gut microbiota, thereby enhancing host digestive efficiency and immune function. Lactobacillus helveticus (LH) supplementation has been shown to improve gut barrier function through modulation of gut immune function. However, no studies have evaluated the effects of LH on barrier function, inflammation, and gut health in ruminants during preweaning and postweaning. Furthermore, there is currently limited information regarding models to study leaky gut in isolation. Previous research has unsuccessfully attempted to create models to induce leaky gut and has focused solely on the systemic inflammatory response without directly assessing gut permeability. Therefore, this proposal aims to improve our understanding of how this digestive disorder impacts host physiology and animal performance. This research encompasses the development of a model to better understand the aetiology of leaky gut and the models generated will serve to evaluate the impact of LH supplementation on barrier function, inflammatory response and energy metabolism.