Metabotropic glutamate receptor dependent long-term depression and calcium signals in FMR1 knockout mice

FMR1 敲除小鼠中代谢型谷氨酸受体依赖性长期抑郁和钙信号

• 批准号: 194069
• 负责人: Li Xiang Yao
• 金额: $ 3.28万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=194069&lang=en
• 关键词: Anterior Cingulate Cortex; Calcium Signal; Fmr1; Fmrp; Glutamatergic Synaptic Transmission; Hippocampus; Long-Term Depression; Mglur-Ltd; Plasticity; Trace Fear Memory

Fragile X syndrome is caused by loss of function of the Fragile X mental retardation gene, FMR1, resulting in a loss of Fragile X Mental Retardation Protein (FMRP). The deficits of FMRP induce moderate-to-severe mental retardation, attention deficits, hy

脆性X综合征是由脆性X智力低下基因FMR 1的功能丧失引起的，导致脆性X智力低下蛋白（FMRP）的丧失。 FMRP缺陷可导致中度至重度精神发育迟滞、注意力缺陷、智力低下、智力低下和智力低下。