Platform to Advance Chromatographic and Photocatalytic Technologies for Applications in Health, Energy and Environment

推进色谱和光催化技术在健康、能源和环境领域应用的平台

• 批准号: RGPIN-2016-04443
• 负责人: RAY, AJAY
• 金额: $ 5.46万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709314
• 关键词: Platform; Advance; Chromatographic; Photocatalytic; Technologies

The proposed research program builds on the strengths of past research efforts undertaken by the applicant on process development of chromatographic and photocatalytic technologies. This program explores to advance knowledge and find solutions in two broad research fields: (a) Chromatography: Recombinant therapeutic protein drugs constitute the fastest growing sector of the bio-pharmaceutical industry both in the amount of products required globally and the number of new drugs undergoing clinical trials. Technological advances in upstream process platform have evolved significantly, both on the cell line production and cell culture bioreactor process fronts, leading to large increases in product titers, diverting challenges to downstream process development mainly for separation and purification that comprise 50-70% of total manufacturing costs. Two classes of downstream purification processing technology are considered: (i) innovative methods for conversion of inactive and misfolded inclusion body proteins produced during bacterial over-expression into soluble bio-active products and its purification, and (ii) efficient platform for purification of antibodies, vaccines and hormones produced in mammalian cells that requires development of new multi-component separation technologies based on solvent gradient approach in multi-column continuous chromatography. (b) Photocatalysis: Photocatalysis is a promising environmentally friendly technology that finds extensive applications in producing clean hydrogen and removal of toxic pollutants. The proposed research will develop transformative natural dye-sensitized solar photocatalysis expertise addressing all challenges impeding its large-scale application for (i) producing high purity sustainable hydrogen energy that does not emit greenhouse gases bypassing entirely the carbon cycle, and (ii) high-rate treatment of micro-pollutants present in water. Our work is aimed at synthesis of new eco-friendly materials, development of innovative process design, inventing new approaches for process intensification, and optimal operation of such process systems. The motivation of the proposed research program is to obtain a deep understanding required to develop the next generation of technologies to produce valuable therapeutic pure health products, new water treatment technologies and energy sources with improved efficiency, process simplicity, and lower costs. The key objectives in the program are to develop an integrated multi-disciplinary comprehensive research and training program for well-rounded graduates with sound technical, scientific, leadership, and entrepreneurial skills. This cutting-edge research is expected to result in state-of-the-art technology development for applications in tomorrow's energy, environment and health, most important global challenges faced by humanity.

拟议的研究计划建立在申请人过去在色谱和光催化技术的工艺开发方面进行的研究工作的优势之上。该计划致力于在两个广泛的研究领域推进知识并寻找解决方案：(a) 色谱法：无论是从全球所需产品的数量还是从正在进行临床试验的新药的数量来看，重组治疗性蛋白药物构成了生物制药行业增长最快的部门。上游工艺平台的技术进步在细胞系生产和细胞培养生物反应器工艺前沿都取得了显着发展，导致产品滴度大幅增加，将挑战转移到主要用于分离和纯化的下游工艺开发，占总制造成本的 50-70%。考虑两类下游纯化加工技术：（i）将细菌过度表达过程中产生的无活性和错误折叠的包涵体蛋白转化为可溶性生物活性产物及其纯化的创新方法，以及（ii）用于纯化哺乳动物细胞中产生的抗体、疫苗和激素的有效平台，需要开发基于溶剂的新型多组分分离技术 多柱连续色谱中的梯度方法。 (b) 光催化：光催化是一种有前景的环保技术，在生产清洁氢气和去除有毒污染物方面有着广泛的应用。拟议的研究将开发变革性的天然染料敏化太阳能光催化专业知识，解决阻碍其大规模应用的所有挑战：（i）生产高纯度可持续氢能，不会完全绕过碳循环排放温室气体，以及（ii）高速处理水中存在的微污染物。 我们的工作旨在合成新型环保材料、开发创新工艺设计、发明工艺强化的新方法以及此类工艺系统的优化运行。拟议研究计划的动机是获得开发下一代技术所需的深入了解，以生产有价值的治疗性纯保健产品、新的水处理技术和能源，提高效率、简化流程并降低成本。该计划的主要目标是为具有良好技术、科学、领导力和创业技能的全面毕业生制定一个综合的多学科综合研究和培训计划。这项尖端研究预计将带来最先进的技术开发，应用于未来的能源、环境和健康，这些是人类面临的最重要的全球挑战。