Sensory Integration and Neural Plasticity of Audition

试听的感觉统合和神经可塑性

• 批准号: RGPIN-2016-04721
• 负责人: Lehmann, Alexandre
• 金额: $ 2.4万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709443
• 关键词: Sensory; Integration; Neural; Plasticity; Audition

The human brain is one of the most complex systems on Earth. Research efforts across the disciplines of the natural sciences and engineering have striven to understand brain function over the last century. While remarkable progress has been made in elucidating key functions underlying sensory and cognitive processes, classical paradigms provide an incomplete picture of human cognition, very much like viewing isolated pieces of a jigsaw puzzle fails to capture the beautiful landscape they can form. Selective attention for instance is one such critical piece: it selects task-relevant features from all the information available in the environment. Selective attention underlies our remarkable ability to attend to one conversation among many in a so-called “cocktail party” situation, by dynamically tracking relevant auditory (voices, background noise) and visual information (lip movements, face and body gestures), integrating them with internal knowledge (semantic structure of the language, context of the conversation) and selecting proper motor commands (such as optimally orienting one's body in space when speakers alternate or concurrent sources appear). The goal of this research program is to gain a deeper theoretical understanding of auditory cognition in humans, its hierarchical dynamics and how it is influenced by the other senses and natural contexts. In particular we will focus on attention and entrainment, two key processes that are dynamically engaged in everyday action and perception, and involve the combination of audition with other senses. To do so we propose a neuro-behavioral framework designed to manipulate the ecological validity of stimuli and the available sensory context. Participant's brain responses, physiological activity as well as their behavior will be recorded, while they perform auditory, and audio-visuo-motor tasks. A cutting-edge technique employing high-density electro-encephalography will be used to simultaneously record activity from both cortical and subcortical structures. Dynamic systems models and tools from the oscillatory theory of cognition will be used to link brain measures with behaviour. Novel knowledge generated on auditory cognitive processes will provide useful evidence to help bridge the gap between isolated mechanisms and their unfolding in real-world cognition. By elucidating critical parameters that affect auditory processing and piecing them together, this program will guide further research towards the understanding of natural cognition and brain function at large.

人脑是地球上最复杂的系统之一。上个世纪，自然科学和工程学各学科的研究工作一直致力于了解大脑功能。虽然在阐明感官和认知过程的关键功能方面已经取得了显着的进展，但经典范式提供了人类认知的不完整图景，就像观看拼图游戏的孤立部分无法捕捉到它们可以形成的美丽景观一样。例如，选择性注意就是这样一个关键部分：它从环境中的所有可用信息中选择与任务相关的特征。选择性注意力是我们在所谓的“鸡尾酒会”情况下参与多人对话的非凡能力的基础，通过动态跟踪相关的听觉（声音、背景噪音）和视觉信息（嘴唇运动、面部和身体姿势），将它们与内部知识（语言的语义结构、对话背景）相结合，并选择适当的运动命令（例如，当说话者交替或同时出现源时，在空间中最佳地定向一个人的身体）。 该研究项目的目标是对人类听觉认知、其层次动态以及它如何受到其他感官和自然环境的影响获得更深入的理论理解。我们将特别关注注意力和夹带，这两个关键过程动态地参与日常行动和感知，并涉及听觉与其他感官的结合。为此，我们提出了一个神经行为框架，旨在操纵刺激的生态有效性和可用的感官环境。参与者在执行听觉和视听运动任务时的大脑反应、生理活动以及行为都会被记录下来。采用高密度脑电图的尖端技术将用于同时记录皮质和皮质下结构的活动。来自认知振荡理论的动态系统模型和工具将用于将大脑测量与行为联系起来。听觉认知过程产生的新知识将提供有用的证据，帮助弥合孤立机制与其在现实世界认知中的展开之间的差距。通过阐明影响听觉处理的关键参数并将它们拼凑在一起，该计划将指导进一步的研究，以理解自然认知和整个大脑功能。