Multimodal Failure Mechanics in the Collagen Fibril
胶原原纤维的多模式失效机制
基本信息
- 批准号:RGPIN-2016-05267
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Collagen's evolutionary longevity is a tribute to the survival value of its complex, self--assembled structure. While both elasticity and overload damage have been studied extensively at the light microscope level in connective tissues, it is below that scalereally at the nanometer scalewhere mechanical load is borne. It is there that collagen's strength is achievedand perhaps more important for survival, where its toughness is determined. For the last 10 years or so, I have been interested in two fundamental questions:
(i) What does mechanical damage in collagen look like at its most fundamental levels?
(ii) Are there structural motifs for damage in collagen that activate physiologically appropriate cellular repair or replacement? These are questions of deep import for understanding the biomechanical evolution of the collagen fibril and for rational design of processed collagen products which can mimic native toughness and modulate inflammation and healing.
We recently demonstrated that overloading of tendon collagen produces a characteristic, local, nano-scaled “kinking” of collagen fibrils (5200 nm dia.). Fibril-level damage leads to thermodynamic instability of the packed collagen molecules, consistent with local denaturation. Enzymolysis and very high magnification SEM (50-70kX) of overloaded tendons have shown that a sub-set (only) of the sub-fibrils at the kink zones are disrupted while others remain. Repeated plastic overload without rupture produces a linear densification of the kinks along individual damaged fibrils. The collagen fibril has thus been revealed to be unexpectedly heterogeneous: both across its diameter and along its length. We have a working theory that the local “kink” failure mechanism has 2--way evolutionary value: toughening tissues like tendons to prevent catastrophic failure while providing the structural cues that guide resorption and/or repair of damaged fibrils. I believe this knowledge can be used.
I propose to further explore the fundamental structuro--mechanical questions which have emerged from our work to date, applying SEM, cryo-TEM, and AFM plus finer-scale, stretch-retained samples to reduce heterogeneity of damage, thereby visualizing kink zone failures before elastic rebound. We will also produce laboratory-extruded collagen fibres to study the extent to which the heterogeneous fibril assembly necessary to the discrete plasticity mechanism is innate to collagen, and what interventions must be applied to produce it for technological value. Finally, we will study the question of whether the serial kink zones which form in damaged fibrils are periodic in nature or stochastically determined. With that knowledge, we will explore fibril-to-fibril propagation of kink formation and seek to produce a model which can couple nanoscale molecular/fibril damage to micron-scale fibre failure.
胶原蛋白的进化寿命是对其复杂的、自我组装的结构的生存价值的致敬。虽然在结缔组织中,弹性损伤和过载损伤已经在光学显微镜水平上进行了广泛的研究,但在纳米尺度上,机械载荷的承受却低于这一尺度。正是在那里,胶原蛋白的强度得以实现,也许对生存更为重要,因为它的韧性是由那里决定的。在过去10年左右的时间里,我一直对两个基本问题感兴趣:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lee, Michael其他文献
Short-term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury
- DOI:
10.1152/jn.00839.2014 - 发表时间:
2015-05-01 - 期刊:
- 影响因子:2.5
- 作者:
Lee, Michael;Kiernan, Matthew C.;Lin, Cindy S. -Y. - 通讯作者:
Lin, Cindy S. -Y.
Generative design for COVID-19 and future pathogens using stochastic multi-agent simulation.
- DOI:
10.1016/j.scs.2023.104661 - 发表时间:
2023-10 - 期刊:
- 影响因子:11.7
- 作者:
Lee, Bokyung;Lau, Damon;Mogk, Jeremy P. M.;Lee, Michael;Bibliowicz, Jacobo;Goldstein, Rhys;Tessier, Alexander - 通讯作者:
Tessier, Alexander
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
- DOI:
10.1186/s13024-023-00633-4 - 发表时间:
2023-06-22 - 期刊:
- 影响因子:15.1
- 作者:
Kang, Moonil;Ang, Ting Fang Alvin;Devine, Sherral A.;Sherva, Richard;Mukherjee, Shubhabrata;Trittschuh, Emily H.;Gibbons, Laura E.;Scollard, Phoebe;Lee, Michael;Choi, Seo-Eun;Klinedinst, Brandon;Nakano, Connie;Dumitrescu, Logan C.;Durant, Alaina;Hohman, Timothy J.;Cuccaro, Michael L.;Saykin, Andrew J.;Kukull, Walter A.;Bennett, David A.;Wang, Li-San;Mayeux, Richard P.;Haines, Jonathan L.;Pericak-Vance, Margaret A.;Schellenberg, Gerard D.;Crane, Paul K.;Au, Rhoda;Lunetta, Kathryn L.;Mez, Jesse B.;Farrer, Lindsay A. - 通讯作者:
Farrer, Lindsay A.
TNF-α inhibitor tanfanercept (HBM9036) improves signs and symptoms of dry eye in a phase 2 trial in the controlled adverse environment in China.
- DOI:
10.1007/s10792-022-02245-1 - 发表时间:
2022-08 - 期刊:
- 影响因子:1.6
- 作者:
Dong, Yanling;Wang, Shuang;Cong, Lin;Zhang, Ting;Cheng, Jun;Yang, Nannan;Qu, Xiaohong;Li, Dongfang;Zhou, Xueying;Wang, Holly;Lee, Michael;Wang, Meng;Chen, Stephen;Ousler, George W.;Chen, Xiaoxiang;Xie, Lixin - 通讯作者:
Xie, Lixin
Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells
- DOI:
10.1007/s10059-011-0034-6 - 发表时间:
2011-03-01 - 期刊:
- 影响因子:3.8
- 作者:
Eum, Ki-Hwan;Lee, Michael - 通讯作者:
Lee, Michael
Lee, Michael的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lee, Michael', 18)}}的其他基金
Multimodal Failure Mechanics in the Collagen Fibril
胶原原纤维的多模式失效机制
- 批准号:
RGPIN-2016-05267 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Impact of high-intensity interval training on leukocyte migratory potential
高强度间歇训练对白细胞迁移潜能的影响
- 批准号:
512987-2017 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
University Undergraduate Student Research Awards
Evaluation of decanoic acid as a neuroprotective agent
癸酸作为神经保护剂的评价
- 批准号:
512279-2017 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
University Undergraduate Student Research Awards
Analysis of AICAR as an activator of lactate transport in neuronal cells
AICAR 作为神经元细胞乳酸转运激活剂的分析
- 批准号:
498051-2016 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
University Undergraduate Student Research Awards
Failure mechanisms in collagen of heart valves and tissue engineered replacements
心脏瓣膜和组织工程替代品胶原蛋白的失效机制
- 批准号:
191922-2010 - 财政年份:2014
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Failure mechanisms in collagen of heart valves and tissue engineered replacements
心脏瓣膜和组织工程替代品胶原蛋白的失效机制
- 批准号:
191922-2010 - 财政年份:2013
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Characterization of translation elongation mechanisms
翻译延伸机制的表征
- 批准号:
433159-2012 - 财政年份:2012
- 资助金额:
$ 2.04万 - 项目类别:
University Undergraduate Student Research Awards
Failure mechanisms in collagen of heart valves and tissue engineered replacements
心脏瓣膜和组织工程替代品胶原蛋白的失效机制
- 批准号:
191922-2010 - 财政年份:2012
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Failure mechanisms in collagen of heart valves and tissue engineered replacements
心脏瓣膜和组织工程替代品胶原蛋白的失效机制
- 批准号:
191922-2010 - 财政年份:2011
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Heat Exchanger and Enclosure Corrosion Improvement
热交换器和外壳腐蚀改善
- 批准号:
419070-2011 - 财政年份:2011
- 资助金额:
$ 2.04万 - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
相似国自然基金
Graphon mean field games with partial observation and application to failure detection in distributed systems
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
相似海外基金
CAREER: Understanding Fiber Bundle Failure Mechanics for Ultra-high Reliability Applications
职业:了解超高可靠性应用的光纤束失效机制
- 批准号:
2339223 - 财政年份:2024
- 资助金额:
$ 2.04万 - 项目类别:
Standard Grant
Influence of Fracture Heterogeneity on Rock Deformation and Failure (INFORM): A Mechanics-based Multi-scale Framework for Radioactive Waste Disposal
裂缝非均质性对岩石变形和破坏的影响(INFORM):基于力学的放射性废物处置多尺度框架
- 批准号:
EP/W031221/2 - 财政年份:2024
- 资助金额:
$ 2.04万 - 项目类别:
Research Grant
Fatigue Failure Mechanics of Polymer-modified Concrete in the Marine Environment
海洋环境中聚合物改性混凝土的疲劳破坏机制
- 批准号:
2882083 - 财政年份:2023
- 资助金额:
$ 2.04万 - 项目类别:
Studentship
Influence of Fracture Heterogeneity on Rock Deformation and Failure (INFORM): A Mechanics-based Multi-scale Framework for Radioactive Waste Disposal
裂缝非均质性对岩石变形和破坏的影响(INFORM):基于力学的放射性废物处置多尺度框架
- 批准号:
EP/W031221/1 - 财政年份:2023
- 资助金额:
$ 2.04万 - 项目类别:
Research Grant
Imaging the Spatial and Temporal Evolution of Frictional Asperities Along the Failure Surface of Creeping Landslides to Illuminate the Mechanics of landslide Friction
对蠕动滑坡破坏面摩擦粗糙度的时空演化进行成像,以阐明滑坡摩擦力学
- 批准号:
2222149 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Continuing Grant
Failure Mechanics of 2D Materials for Advanced Coatings and Composites
先进涂层和复合材料的二维材料的失效力学
- 批准号:
RGPIN-2019-04418 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Mechanics of Granular Materials: Rigidity, Nonlocality, and Activated Failure
颗粒材料力学:刚性、非局域性和激活失效
- 批准号:
2104986 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Continuing Grant
Identifying Spatial Variation in Soft Tissue Mechanics and Predicting Failure: Application to Cardiac Rupture
识别软组织力学的空间变化并预测失败:在心脏破裂中的应用
- 批准号:
2030173 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Standard Grant
Failure Mechanics of 2D Materials for Advanced Coatings and Composites
先进涂层和复合材料的二维材料的失效力学
- 批准号:
RGPIN-2019-04418 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Multimodal Failure Mechanics in the Collagen Fibril
胶原原纤维的多模式失效机制
- 批准号:
RGPIN-2016-05267 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual














{{item.name}}会员




