Image Reconstruction and Processing in Dynamic Computed Tomography

动态计算机断层扫描中的图像重建和处理

• 批准号: RGPIN-2016-06565
• 负责人: So, Aaron
• 金额: $ 1.75万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710319
• 关键词: Image; Reconstruction; Processing; Dynamic; Computed

Dynamic contrast enhanced computed tomography (DCE-CT) is a widely used non-invasive imaging test for assessing microvascular hemodynamics in various tissue injuries and diseases. This method relies on scanning the tissue of interest with a CT scanner for a short period of time (half to few minutes) after injecting x-ray dye. One limitation of this approach is potential cancer risk from exposure to x-rays (ionizing radiation). Radiation induced injury can be minimized by scanning with much less x-rays but the resulting image errors will affect the evaluation of physiological parameters assessed with DCE-CT (similar to the excessive noise in low-light photography). In this research program, we will implement new image reconstruction and processing methods to minimize errors in DCE-CT images acquired from extremely low radiation scanning. The proposed methods will be optimized using phantoms and validated in animals against gold standards. We anticipate that this research will lead to a significant reduction in radiation exposure in DCE CT studies and facilitate a wider use of DCE-CT for assessing the pathophysiology of various diseases and for therapeutic drug development. The proposed research program will also provide excellent opportunities for trainees to pursue impactful imaging research in an environment with experienced mentors and state-of-the-art imaging facilities.

动态对比增强计算机断层扫描（DCE-CT）是一种广泛使用的非侵入性成像测试，用于评估各种组织损伤和疾病的微血管血流动力学。这种方法依赖于在注射X射线染料后用CT扫描仪扫描感兴趣的组织一段短的时间（半分钟到几分钟）。这种方法的一个局限性是暴露于X射线（电离辐射）的潜在癌症风险。通过使用更少的X射线进行扫描，可以最大限度地减少辐射引起的损伤，但由此产生的图像误差将影响DCE-CT评估的生理参数的评价（类似于低光摄影中的过度噪声）。在这项研究计划中，我们将实施新的图像重建和处理方法，以最大限度地减少从极低辐射扫描获得的DCE-CT图像中的误差。所提出的方法将使用phantomy进行优化，并在动物中对照金标准进行验证。我们预计，这项研究将导致显着减少在DCE CT研究中的辐射暴露，并促进更广泛地使用DCE-CT评估各种疾病的病理生理学和治疗药物的开发。拟议的研究计划还将为学员提供绝佳的机会，在经验丰富的导师和最先进的成像设施的环境中进行有影响力的成像研究。