The Development of Enabling Syntheic Methodologies and Application to the Synthesis of Natural Products

本提案描述了我们的计划正在进行的进展和新的方向，该计划旨在开发新的合成有机反应及其在合成通常具有生物或医学重要性的重要目标分子方面的应用。这类反应围绕以下几个主题：1.给体环丙烷用于碳环和杂环的合成，2.杂环基团的自由基和卡宾功能化，3.新的偶极环加成反应的开发，以及4.将这些过程的产物精化成有机化学界感兴趣的分子骨架。 选择用于合成的目标分子通常被选为我们开发的反应的展示窗口，然而在某些情况下，它们被选为纯粹的复杂性和不寻常的结构。我们的研究计划给化学界带来了两方面的好处：1.我们开发的方法将是合成化学家化学武器库的可喜补充；2.面向目标的合成项目为合成化学家提供了已知的最好的培训环境，使其能够继续从事工业或学术方面的后续工作。

This proposal describes the ongoing progress and new directions of our program which is aimed at developing new synthetic organic reactions and their application to the synthesis of important target molecules, usually of biological or medical importance. Such reactions center around several themes: 1. The use of donor-acceptor cyclopropanes for the synthesis of carbocycles and heterocycles, 2. The radical and carbenoid functionalization of heterocyclic motifs, 3. The development of new dipolar cycloaddiitons, and 4. The elaboration of the products from these processes into molecular frameworks of interest to the organic chemical community. The target molecules selected for synthesis are often chosen as a showcase for the reactions we develop, however in some cases they are chosen for their sheer complexity and unusual structures. The benefits of our research program to the chemical community are twofold: 1. The methods we develop will be welcome additions to the chemical arsenal of the synthetic chemist and 2. The projects of target oriented synthesis provide the best training milieu known for synthetic chemists moving forward to subsequent endeavors, industrial or academic.