The Development of Enabling Syntheic Methodologies and Application to the Synthesis of Natural Products

该提案描述了我们计划的持续进展和新方向，该计划旨在开发新的合成有机反应及其在合成重要目标分子（通常具有生物或医学重要性）中的应用。 这些反应围绕着几个主题：1。给体-受体环丙烷在合成碳环和杂环中的应用，2.杂环基序的自由基和类卡宾功能化，3。发展了新的偶极环加成反应; 4.将这些过程的产物加工成有机化学界感兴趣的分子框架。 选择用于合成的目标分子通常被选择作为我们开发的反应的展示，然而在某些情况下，它们被选择用于其纯粹的复杂性和不寻常的结构。 我们的研究计划对化学界的好处是双重的：1。我们开发的方法将是合成化学家和2的化学武器库的受欢迎的补充。目标导向合成的项目为合成化学家提供了最好的培训环境，使他们能够继续从事工业或学术工作。

This proposal describes the ongoing progress and new directions of our program which is aimed at developing new synthetic organic reactions and their application to the synthesis of important target molecules, usually of biological or medical importance. Such reactions center around several themes: 1. The use of donor-acceptor cyclopropanes for the synthesis of carbocycles and heterocycles, 2. The radical and carbenoid functionalization of heterocyclic motifs, 3. The development of new dipolar cycloaddiitons, and 4. The elaboration of the products from these processes into molecular frameworks of interest to the organic chemical community. The target molecules selected for synthesis are often chosen as a showcase for the reactions we develop, however in some cases they are chosen for their sheer complexity and unusual structures. The benefits of our research program to the chemical community are twofold: 1. The methods we develop will be welcome additions to the chemical arsenal of the synthetic chemist and 2. The projects of target oriented synthesis provide the best training milieu known for synthetic chemists moving forward to subsequent endeavors, industrial or academic.