Nanoporous Media in Analytical Sciences

分析科学中的纳米多孔介质

• 批准号: RGPIN-2018-06646
• 负责人: Harrison, DJed
• 金额: $ 2.62万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=714377
• 关键词: Nanoporous; Media; Analytical; Sciences

The program proposed utilizes microfluidic technologies to enhance biochemical analysis and clinical diagnostics in one area of application. In another, we will provide a deeper understanding of transport in nanoporous media for better modeling of water, oil and natural gas in fractured solid media (rocks). The program will improve separation methods for proteins, develop centrifugal microfluidic devices and engineered surfaces for improved clinical diagnostics of metabolites. It will also provide fundamental data on transport in nanoporous media that will be of benefit in the modeling and understanding of transport in fractured rock, so as to aid in enhanced oil and gas recovery. The development and exploitation of nanoporous materials is the central theme to each of the applications pursued in this work. Nanoporous materials can be rationally designed to enhance the desired properties of a material for applications in chemical and biochemical analysis. In our program we are utilizing both a self-assembled and a manufacturing methodology to create nanoporous devices, and surfaces, with applications in the life sciences. Our focus is on protein separation, and in peptide, protein and metabolite mass spectrometry. The fabrication techniques allow us to engineer the pore size, order and material properties of the nanoporous media, which, combined with surface chemistry controls the properties and performance of the materials. We will be able to improve analytical performance, or create new means of analysis, using our methods of fabrication of nanoporous materials. In a different application of nanoporous materials, we will utilize the fine control of porosity that our methods allow, to provide a deeper understanding of transport in nanoporous media. In fractured rock media a combination of large and small scale regimes exist, but since the fluid mechanics of nanopores are not well understood they become more challenging to model mathematically in terms of predicting overall transport and liquid recovery outcomes. This work will provide experimental results that allows improved modeling of transport and recovery in mixed size scale medium such as porous rock, through experimentally measuring the parameters of the smallest pore sizes.

该计划利用微流控技术在一个应用领域加强生化分析和临床诊断。 在另一个，我们将提供更深入的了解在纳米多孔介质中的运输，更好地模拟水，石油和天然气在裂缝固体介质（岩石）。该计划将改进蛋白质的分离方法，开发离心微流体设备和工程表面，以改善代谢物的临床诊断。它还将提供有关纳米多孔介质中运输的基本数据，这些数据将有利于对断裂岩石中运输的建模和理解，从而有助于提高石油和天然气采收率。 纳米多孔材料的开发和利用是这项工作中追求的每个应用的中心主题。 纳米多孔材料可以被合理地设计以增强用于化学和生物化学分析的材料的期望性质。 在我们的计划中，我们利用自组装和制造方法来创建纳米多孔设备和表面，并在生命科学中应用。 我们的重点是蛋白质分离，肽，蛋白质和代谢物质谱。 制造技术使我们能够设计纳米多孔介质的孔径，顺序和材料特性，结合表面化学控制材料的特性和性能。我们将能够提高分析性能，或创造新的分析手段，使用我们的纳米多孔材料的制造方法。 在纳米多孔材料的不同应用中，我们将利用我们的方法允许的孔隙率的精细控制，以提供对纳米多孔介质中的传输的更深入的理解。在断裂岩石介质中，存在大尺度和小尺度机制的组合，但由于纳米孔的流体力学尚未得到很好的理解，因此在预测整体运输和液体回收结果方面，它们变得更具挑战性。这项工作将提供实验结果，允许改进的模型的运输和恢复在混合尺寸尺度介质，如多孔岩石，通过实验测量的最小孔径的参数。