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To study the pathogenesis and its underlying mechanisms of an abnormally large Pol II pool size caused by a defective novel ARMC5-containing POLR2A-specific ubiquitin ligase

To study the pathogenesis and its underlying mechanisms of an abnormally large Pol II pool size caused by a defective novel ARMC5-containing POLR2A-specific ubiquitin ligase
研究由含有 ARMC5 的新型 POLR2A 特异性泛素连接酶缺陷引起的异常大的 Pol II 池大小的发病机制及其潜在机制
批准号：
450595
负责人：
Wu Jiangping
金额：
$56.84万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=450595&lang=en
关键词：
Adrenal Gland Hyperplasia Armc5 Neural Tube Defects Pol Ii Pool Size Polr2a (Rpb1) Protein Degradation Rna Polymerase Ii (Pol Ii) Ubiquitin Ligase

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英文摘要
We recently found that a molecule called ARMC5 is part of an enzyme called ubiquitin ligase (E3). Its target is a molecule called POLR2A, which is involved in messenger RNA synthesis. This ligase will mark POLR2A for destruction. In mice and humans with
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