ARMC5 and other genetic contributions in endocrine neoplasia

ARMC5 和其他遗传因素在内分泌肿瘤中的作用

• 批准号: nhmrc : 1115188
• 负责人: Dr Sunita De Sousa
• 金额: $ 8.31万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/armc5-genetic-contributions-endocrine-neoplasia/663367
• 关键词: ARMC5; other; genetic; contributions; endocrine

The adrenal glands secrete essential hormones and can enlarge or develop tumours leading to conditions including obesity, high blood pressure, diabetes, brittle bones and infections. We recently found that adrenal enlargement and tumours may be due to changes in the ARMC5 gene. We will perform genetic testing in affected patients across Australia to evaluate the roles of ARMC5 & other genes. Our goal is to better understand how these conditions develop so as to improve diagnosis and treatment.

肾上腺分泌必需的激素，可以扩大或发展肿瘤，导致肥胖，高血压，糖尿病，骨质疏松和感染等疾病。我们最近发现，肾上腺肿大和肿瘤可能是由于ARMC 5基因的变化。我们将对澳大利亚各地受影响的患者进行基因检测，以评估ARMC5和其他基因的作用。我们的目标是更好地了解这些疾病是如何发展的，以改善诊断和治疗。