The cardiac-sympathetic contribution to blood pressure regulation

心脏交感神经对血压调节的贡献

基本信息

  • 批准号:
    RGPIN-2020-06240
  • 负责人:
  • 金额:
    $ 2.77万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

The arterial baroreflex is arguably one of the most important reflexes in the control of arterial blood pressure (BP). The baroreflex buffers acute fluctuations in BP that occur during physiological stressors by controlling cardiac output and total peripheral resistance. Thus the output' from the baroreflex is considered to consist of a heart rate (cardiopulmonary arm) and vascular component (sympathetic arm). In conducting integrative physiological studies in rodents with spinal transection over the last 5-8 years, my lab has made a number of key observations that imply there may also be a cardiac inotropic (i.e., cardiac-sympathetic) arm to the arterial baroroeflex. Recently, we have found that when the arterial baroreceptors are unloaded there is not only an increase in peripheral vascular resistance and heart rate but there is also an increase in cardiac inotropic function. Though such a response is logical, direct evidence supporting the presence of a cardiac-inotropic arm to the arterial baroreflex control of blood pressure is lacking. Moreover, fundamental shortcomings exist in our understanding of the neuroanatomical pathways that are important in transducing this response from the brainstem to the heart and blood vessels. Over the next 5 years we will comprehensively study the presence of a functional cardiac-inotropic arm to the baroreflex along with the underlying neuroanatomic pathways that control this response, with a particular emphasis on spinal segmental control. We will specifically assess whether mechanical and pharmacological manipulation of the baroreflex results in similar cardiac and vascular outputs, as well as testing whether control mechanisms differ by sex and are impacted by activation of the chemoreflex. We will also continue our ongoing efforts to modify the post-processing software available for human sympathetic recordings to study and decode sympathetic neural transmission in rodents, wherein we will additionally relate such strategies to end-organ function. Establishing and validating the presence of a functional cardiac-inotropic arm to the baroreflex and determining the underlying neuroanatomical control is expected to advance our basic understanding of how the baroreflex functions to maintain arterial blood pressure. The studies proposed span a number of diverse fields and provide an excellent training environment for HQP who will be trained in all aspects of the surgical preparation and advanced data processing.
动脉压力反射可以说是控制动脉血压的最重要的反射之一。压力反射通过控制心输出量和总外周阻力来缓冲生理应激时发生的急性血压波动。因此,压力反射的输出被认为是由心率(心肺臂)和血管成分(交感臂)组成的。在过去的5-8年里,在对脊椎横断的啮齿动物进行综合生理学研究时,我的实验室进行了一些关键的观察,这些观察表明,动脉血压弯曲可能也存在心脏肌力(即心脏交感神经)臂。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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West, Christopher其他文献

The Cleft Multidisciplinary Collaborative: Establishing a Network to Support Cleft Lip and Palate Research in the United Kingdom
  • DOI:
    10.1177/1055665618790174
  • 发表时间:
    2019-04-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Sainsbury, David C. G.;Davies, Amy;West, Christopher
  • 通讯作者:
    West, Christopher
The Role of Autonomic Function on Sport Performance in Athletes With Spinal Cord Injury
  • DOI:
    10.1016/j.pmrj.2014.05.023
  • 发表时间:
    2014-08-01
  • 期刊:
  • 影响因子:
    2.1
  • 作者:
    Krassioukov, Andrei;West, Christopher
  • 通讯作者:
    West, Christopher
Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
  • DOI:
    10.3791/52809
  • 发表时间:
    2016-07-01
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    Popok, David;West, Christopher;Krassioukov, Andrei V.
  • 通讯作者:
    Krassioukov, Andrei V.

West, Christopher的其他文献

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{{ truncateString('West, Christopher', 18)}}的其他基金

The cardiac-sympathetic contribution to blood pressure regulation
心脏交感神经对血压调节的贡献
  • 批准号:
    RGPIN-2020-06240
  • 财政年份:
    2022
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Grants Program - Individual
Development of a triple haemodynamic monitoring system for mammalian physiology studies
用于哺乳动物生理学研究的三重血流动力学监测系统的开发
  • 批准号:
    565734-2021
  • 财政年份:
    2021
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Alliance Grants
The cardiac-sympathetic contribution to blood pressure regulation
心脏交感神经对血压调节的贡献
  • 批准号:
    RGPIN-2020-06240
  • 财政年份:
    2021
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Grants Program - Individual
The cardiac-sympathetic contribution to blood pressure regulation
心脏交感神经对血压调节的贡献
  • 批准号:
    DGECR-2020-00128
  • 财政年份:
    2020
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Launch Supplement
Using fossil megafloras to interpret change in Arctic climate and ecosystems in the geological past
利用巨型植物群化石解释过去地质时期北极气候和生态系统的变化
  • 批准号:
    489026-2016
  • 财政年份:
    2018
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Using fossil megafloras to interpret change in Arctic climate and ecosystems in the geological past
利用巨型植物群化石解释过去地质时期北极气候和生态系统的变化
  • 批准号:
    489026-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Using fossil megafloras to interpret change in Arctic climate and ecosystems in the geological past
利用巨型植物群化石解释过去地质时期北极气候和生态系统的变化
  • 批准号:
    489026-2016
  • 财政年份:
    2016
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Postgraduate Scholarships - Doctoral

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The cardiac-sympathetic contribution to blood pressure regulation
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    RGPIN-2020-06240
  • 财政年份:
    2022
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Grants Program - Individual
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The cardiac-sympathetic contribution to blood pressure regulation
心脏交感神经对血压调节的贡献
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    RGPIN-2020-06240
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    Discovery Grants Program - Individual
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