Dendritic inhibition in hippocampal circuits

每一件重要的事件和每一件重要的生活事件都是通过组成海马体的几种不同类型的细胞之间的协调对话在我们的大脑中编码的。这种结构由谷氨酸能主细胞(PC)和高度多样化的GABA能抑制中间神经元(INS)组成。在海马CA1区，INS的形态、分子和功能分析已经确定了21种不同的细胞类型(Klausberger和Somogyi，2008)。有趣的是，这些细胞中的大多数(21种类型中的18种)在PC和INS的不同树突域上形成突触，因此可能控制传入信号和控制树突状细胞的兴奋性。这项拟议的研究旨在通过分析树突靶向INS的细胞类型和突触特异性作用来解释为什么在海马CA1区的信息处理中需要如此多样化的树突抑制源。这项研究的结果将解释聚集在海马神经元树突上的抑制输入的多样性，并将阐明局部微电路连接如何以细胞类型和突触特有的方式控制单个神经元的计算能力。

Every important event and every significant life episode is encoded in our brain through a concerted dialogue between several distinct cell types that make up the hippocampal formation. This structure comprises glutamatergic principal cells (PCs) and a highly diverse population of GABAergic inhibitory interneurons (INs). In the hippocampal CA1 area the output region of the hippocampus morphological, molecular, and functional analyses of INs have identified 21 different cell types (Klausberger and Somogyi, 2008). Intriguingly, the majority of these cells (18 of the 21 types) form synapses on different dendritic domains of PCs and INs, and may therefore gate afferent signals and control dendritic excitability. The proposed research aims to explain why such a diversity of dendritic inhibitory sources is required for information processing within the hippocampal CA1 area by analyzing the cell-type and synapse-specific roles of the dendrite-targeting INs. The results of this research will explain the diversity of inhibitory inputs that converge on hippocampal neuronal dendrites and will shed light on how the local microcircuit wiring may control the computational power of individual neurons in a cell-type and synapse-specific manner.