Dendritic inhibition in hippocampal circuits

海马回路中的树突抑制

• 批准号: RGPIN-2020-04939
• 负责人: Topolnik, LisaYelyzaveta
• 金额: $ 4.23万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=740300
• 关键词: Dendritic; inhibition; hippocampal; circuits

Every important event and every significant life episode is encoded in our brain through a concerted dialogue between several distinct cell types that make up the hippocampal formation. This structure comprises glutamatergic principal cells (PCs) and a highly diverse population of GABAergic inhibitory interneurons (INs). In the hippocampal CA1 area - the output region of the hippocampus - morphological, molecular, and functional analyses of INs have identified 21 different cell types (Klausberger and Somogyi, 2008). Intriguingly, the majority of these cells (18 of the 21 types) form synapses on different dendritic domains of PCs and INs, and may therefore gate afferent signals and control dendritic excitability. The proposed research aims to explain why such a diversity of dendritic inhibitory sources is required for information processing within the hippocampal CA1 area by analyzing the cell-type and synapse-specific roles of the dendrite-targeting INs. The results of this research will explain the diversity of inhibitory inputs that converge on hippocampal neuronal dendrites and will shed light on how the local microcircuit wiring may control the computational power of individual neurons in a cell-type and synapse-specific manner.

每一个重要的事件和每一个重要的生活插曲都是通过组成海马结构的几种不同细胞类型之间的协调对话在我们的大脑中编码的。这种结构包括谷氨酸能主细胞（PC）和高度多样化的GABA能抑制性中间神经元（IN）。在海马CA1区（海马的输出区），通过对IN的形态学、分子和功能分析，鉴定出21种不同的细胞类型（Klausberger和Somogyi，2008）。有趣的是，这些细胞中的大多数（21种类型中的18种）在PC和IN的不同树突结构域上形成突触，因此可以门控传入信号并控制树突兴奋性。这项研究旨在通过分析树突的细胞类型和突触特异性作用，解释为什么海马CA1区的信息处理需要如此多样的树突抑制源。这项研究的结果将解释收敛在海马神经元树突上的抑制性输入的多样性，并将阐明局部微电路布线如何控制计算性神经元树突。以细胞类型和突触特异性方式增强单个神经元的能力。