Enhancing gastrointestinal development and functionality in chickens through fiber nutrition
通过纤维营养增强鸡的胃肠道发育和功能
基本信息
- 批准号:RGPIN-2020-05535
- 负责人:
- 金额:$ 1.75万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Globally, chicken meat is one of the most popular sources of animal protein for human consumption, with increasing consumer demand, which is associated with its health benefit and low environmental footprint. Traditionally, antibiotics have been used to prevent enteric diseases in poultry production. However, there is progressive decline in the use of antibiotics in many parts of the world, because of increase in development of antibiotic resistant bacteria, which poses threats to human health. Consequently, there is increasing risk of colonization by pathogenic bacteria that can impair chicken health and cause food-borne infections in humans, resulting in significant economic losses. Functional gastrointestinal tract (GIT) is a proven tool to prevent these infections, because disruption of intestinal mucosa and microflora are the essential mechanisms by which pathogens cause havoc to poultry. Dietary fiber, rich in phenolic compounds (DF-PC) from locally available materials such as seaweed (SW), grape pomace (GP) and red osier dogwood (Cornus stolonifera; ROD) can serve as multiple-edged sword to promote chicken GIT functionality by preventing oxidative stress (phenolic fraction) and improving GIT epithelial integrity (non-starch polysaccharide fractions), without reducing growth performance. It is more likely that this combinational approach will achieve the needed breakthrough to eliminate or reduce the use of antibiotics in poultry production. The long term goal of my research program is to investigate bioactive compounds and novel delivery strategies for optimal growth and GIT health and development of chickens. The short term objectives of the next five year cycle are to: 1) Characterize SW, GP, and ROD and identify their potential prebiotic components for chickens; 2) investigate gut morphology, gene expression of tight junction proteins, SCFA production and gut microbial population in chickens fed SW, GP, ROD and their enzymatically-released bioactive components; and 3) Develop in ovo delivery strategy for enzymatically-released bioactive components of SW in broiler chickens and the effect on GIT integrity during disease challenge conditions. The proposed studies will result in improvement of GIT functionality and development in chickens, improve nutrient utilization, minimize the risk of bacterial infections and reduce dependence on antibiotics in chicken production. The establishment of a healthy GIT environment in broiler chickens offers an opportunity to reduce cost of production and consequently increase profitability and sustainability. The results of this project will also provide control measures for the associated human illnesses, as well as reducing the incidence of antibiotic resistance, thus reducing Canada's expenditure on healthcare. The research will offer an excellent opportunity to train 6 HQPs (2 PhD, 2 MSc and 2 Undergraduate students) and equip them with experience that will further advance the Canadian economy.
在全球范围内,鸡肉是人类消费最受欢迎的动物蛋白来源之一,消费者需求不断增加,这与其健康益处和低环境足迹有关。传统上,抗生素已被用于预防家禽生产中的肠道疾病。然而,在世界许多地方,抗生素的使用逐渐减少,因为抗生素抗性细菌的发展增加,这对人类健康构成威胁。因此,致病菌定植的风险越来越大,这些致病菌可能损害鸡的健康,并导致人类食源性感染,造成重大经济损失。功能性胃肠道(GIT)是预防这些感染的有效工具,因为肠粘膜和微生物菌群的破坏是病原体对家禽造成严重破坏的基本机制。富含酚类化合物(DF-PC)的膳食纤维来自当地可用的材料,如海藻(SW)、葡萄渣(GP)和红柳山茱萸(Cornus stolonifera; ROD),可以作为多刃剑,通过防止氧化应激(酚级分)和改善GIT上皮完整性(非淀粉多糖级分)来促进鸡GIT功能,而不降低生长性能。这种组合方法更有可能实现所需的突破,以消除或减少家禽生产中抗生素的使用。我的研究计划的长期目标是研究生物活性化合物和新的交付策略,以实现鸡的最佳生长和GIT健康和发育。下一个五年周期的短期目标是:1)表征SW、GP和ROD并鉴定其对鸡的潜在益生元组分; 2)研究饲喂SW、GP、ROD及其酶促释放的生物活性组分的鸡的肠道形态、紧密连接蛋白的基因表达、SCFA产生和肠道微生物种群;以及3)开发SW在肉鸡中酶促释放的生物活性组分的卵内递送策略以及在疾病攻击条件下对GIT完整性的影响。拟议的研究将改善鸡的GIT功能和发育,提高营养利用率,最大限度地减少细菌感染的风险,并减少鸡生产中对抗生素的依赖。在肉鸡中建立健康的GIT环境提供了降低生产成本的机会,从而提高盈利能力和可持续性。该项目的成果还将为相关的人类疾病提供控制措施,并减少抗生素耐药性的发生率,从而减少加拿大的医疗保健支出。这项研究将提供一个极好的机会,培养6名HQP(2名博士,2名硕士和2名本科生),并为他们提供进一步推动加拿大经济发展的经验。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Adewole, Deborah其他文献
An evaluation of the thermoregulatory potential of in ovo delivered bioactive substances (probiotic, folic acid, and essential oil) in broiler chickens.
- DOI:
10.1016/j.psj.2023.102602 - 发表时间:
2023-05 - 期刊:
- 影响因子:4.4
- 作者:
Oladokun, Samson;Dridi, Sami;Adewole, Deborah - 通讯作者:
Adewole, Deborah
Effect of Dietary Supplementation with Coarse or Extruded Oat Hulls on Growth Performance, Blood Biochemical Parameters, Ceca Microbiota and Short Chain Fatty Acids in Broiler Chickens
- DOI:
10.3390/ani10081429 - 发表时间:
2020-08-01 - 期刊:
- 影响因子:3
- 作者:
Adewole, Deborah - 通讯作者:
Adewole, Deborah
Research Note: Non-invasive urate sphere corticosterone metabolite as a novel biomarker for heat stress in poultry.
- DOI:
10.1016/j.psj.2024.103439 - 发表时间:
2024-03 - 期刊:
- 影响因子:4.4
- 作者:
Oladokun, Samson;Adewole, Deborah - 通讯作者:
Adewole, Deborah
Probiotics, prebiotics, and synbiotics: an overview of their delivery routes and effects on growth and health of broiler chickens
- DOI:
10.1080/00439339.2022.1988804 - 发表时间:
2021-11-02 - 期刊:
- 影响因子:2.7
- 作者:
Khomayezi, Rojman;Adewole, Deborah - 通讯作者:
Adewole, Deborah
Determination of the net energy content of canola meal from Brassica napus yellow and Brassica juncea yellow fed to growing pigs using indirect calorimetry
- DOI:
10.1111/asj.12196 - 发表时间:
2014-07-01 - 期刊:
- 影响因子:2
- 作者:
Heo, Jung Min;Adewole, Deborah;Nyachoti, Martin - 通讯作者:
Nyachoti, Martin
Adewole, Deborah的其他文献
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{{ truncateString('Adewole, Deborah', 18)}}的其他基金
Enhancing gastrointestinal development and functionality in chickens through fiber nutrition
通过纤维营养增强鸡的胃肠道发育和功能
- 批准号:
RGPIN-2020-05535 - 财政年份:2022
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
A functional blend of botanical extracts to enhance enrichment use and natural behaviours in laying hens
植物提取物的功能性混合物,可增强蛋鸡的浓缩使用和自然行为
- 批准号:
561354-2020 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Alliance Grants
Enhancing gastrointestinal development and functionality in chickens through fiber nutrition
通过纤维营养增强鸡的胃肠道发育和功能
- 批准号:
RGPIN-2020-05535 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Transcriptomic responses of in ovo delivered bioactive substances in heat-stressed broiler chickens
热应激肉鸡卵内传递生物活性物质的转录组反应
- 批准号:
571288-2021 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Alliance Grants
Enhancing gastrointestinal development and functionality in chickens through fiber nutrition
通过纤维营养增强鸡的胃肠道发育和功能
- 批准号:
DGECR-2020-00108 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Launch Supplement
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