Neuromuscular mechanisms for cold-induced changes in voluntary and involuntary muscle activity

寒冷引起的随意和不随意肌肉活动变化的神经肌肉机制

• 批准号: RGPIN-2020-06218
• 负责人: Giesbrecht, Gordon
• 金额: $ 2.04万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718265
• 关键词: Neuromuscular; mechanisms; cold; induced; changes

Hundreds of Canadians die annually from cold exposure, often during cold-water immersion. Survival and recovery can be improved by understanding our body's physiological responses to cold. My research program focuses on physiologic mechanisms contributing to enhancing physical performance and survival in the cold. Thus, I intend to further study mechanisms for, and implications of cold-induced reduction in voluntary muscle activity and involuntary shivering. Magnetic stimulation (MS) and electrical stimulation (ES) of muscle activity, will identify effects of local muscle and/or body core cooling on excitatory and inhibitory neural pathways. Transcranial MS (at the top of the skull) stimulates the entire motor pathway from corticospinal neurons, to motor neuron, to muscle. Cervico-medullary ES (at the base of the skull) specifically stimulates spinal motor neurons. We will also specifically explore the effects of cooling the body core and/or the local muscle during brief and fatiguing voluntary muscle contractions. Therefore, we can differentiate between local and central neural circuits and whether they are excitatory or inhibitory, and determine the proportional contribution of each. These techniques will also help determine central mechanisms that account for submaximal shivering intensity, even when core temperature is decreasing (a condition when one would expect a maximal response but it is not). During many of the studies in this research program, we will determine if there is an effect of sex on the responses. Results could direct future research to maximize muscle contraction and shivering during cold-water survival situations. Finally, if there are sex effects, female data may be used to improve cold survival models used by the Canadian Coast Guard. I intend to train 8-10 HQP in the next 5 years, who will become exercise scientists, university professors, physicians and physiotherapists. Some of these HQP will be involved in teaching or coaching on topics that will improve both performance, safe participation and survival in extreme environments.

每年有数百名加拿大人死于寒冷，通常是在冷水中浸泡。通过了解我们身体对寒冷的生理反应，生存和恢复可以得到改善。我的研究项目主要集中在提高身体机能和在寒冷中生存的生理机制。因此，我打算进一步研究冷诱导的随意肌肉活动和不自主颤抖减少的机制和影响。肌肉活动的磁刺激（MS）和电刺激（ES）将识别局部肌肉和/或身体核心冷却对兴奋性和抑制性神经通路的影响。经颅多发性硬化症（位于颅骨顶部）刺激从皮质脊髓神经元到运动神经元再到肌肉的整个运动通路。颈髓ES（颅骨底部）特别刺激脊髓运动神经元。我们还将特别探讨在短暂和疲劳的随意肌收缩期间冷却身体核心和/或局部肌肉的效果。因此，我们可以区分局部和中枢神经回路，以及它们是兴奋性的还是抑制性的，并确定各自的比例贡献。这些技术也将有助于确定解释亚最大颤抖强度的核心机制，即使当核心温度下降时（人们期望最大反应，但事实并非如此）。在这个研究项目的许多研究中，我们将确定性别是否对反应有影响。结果可以指导未来的研究，最大限度地提高肌肉收缩和颤抖在冷水生存的情况下。最后，如果存在性别影响，女性数据可以用来改进加拿大海岸警卫队使用的寒冷生存模型。我计划在未来5年内培养8-10名HQP，他们将成为运动科学家、大学教授、医生和物理治疗师。其中一些HQP将参与教学或指导的主题，将提高性能，安全参与和生存在极端环境。