Neuromuscular mechanisms for cold-induced changes in voluntary and involuntary muscle activity

每年有数百名加拿大人死于寒冷，通常是在冷水浸泡期间。通过了解我们身体对寒冷的生理反应，可以提高生存和恢复。我的研究计划侧重于生理机制有助于提高身体表现和生存在寒冷中。因此，我打算进一步研究冷诱导的随意肌肉活动减少和不自主颤抖的机制和影响。肌肉活动的磁刺激（MS）和电刺激（ES）将识别局部肌肉和/或身体核心冷却对兴奋性和抑制性神经通路的影响。经颅多发性硬化症（位于颅骨顶部）刺激从皮质脊髓神经元到运动神经元再到肌肉的整个运动通路。 颈髓ES（位于颅底）特异性刺激脊髓运动神经元。我们还将专门探讨在短暂和疲劳的随意肌肉收缩期间冷却身体核心和/或局部肌肉的效果。 因此，我们可以区分局部和中枢神经回路，以及它们是兴奋性的还是抑制性的，并确定各自的比例贡献。这些技术还将有助于确定导致次最大颤抖强度的中枢机制，即使核心温度正在下降（一种预期最大反应但实际上并非如此的情况）。在这项研究计划的许多研究中，我们将确定性别对反应是否有影响。结果可以指导未来的研究，以最大限度地提高肌肉收缩和颤抖在冷水中生存的情况。最后，如果有性别效应，女性数据可能会被用来改善加拿大海岸警卫队使用的寒冷生存模型。我打算在未来5年内培养8-10名HQP，他们将成为运动科学家，大学教授，医生和物理治疗师。 其中一些HQP将参与教学或辅导主题，以提高在极端环境中的表现，安全参与和生存。

Hundreds of Canadians die annually from cold exposure, often during cold-water immersion. Survival and recovery can be improved by understanding our body's physiological responses to cold. My research program focuses on physiologic mechanisms contributing to enhancing physical performance and survival in the cold. Thus, I intend to further study mechanisms for, and implications of cold-induced reduction in voluntary muscle activity and involuntary shivering. Magnetic stimulation (MS) and electrical stimulation (ES) of muscle activity, will identify effects of local muscle and/or body core cooling on excitatory and inhibitory neural pathways. Transcranial MS (at the top of the skull) stimulates the entire motor pathway from corticospinal neurons, to motor neuron, to muscle. Cervico-medullary ES (at the base of the skull) specifically stimulates spinal motor neurons. We will also specifically explore the effects of cooling the body core and/or the local muscle during brief and fatiguing voluntary muscle contractions. Therefore, we can differentiate between local and central neural circuits and whether they are excitatory or inhibitory, and determine the proportional contribution of each. These techniques will also help determine central mechanisms that account for submaximal shivering intensity, even when core temperature is decreasing (a condition when one would expect a maximal response but it is not). During many of the studies in this research program, we will determine if there is an effect of sex on the responses. Results could direct future research to maximize muscle contraction and shivering during cold-water survival situations. Finally, if there are sex effects, female data may be used to improve cold survival models used by the Canadian Coast Guard. I intend to train 8-10 HQP in the next 5 years, who will become exercise scientists, university professors, physicians and physiotherapists. Some of these HQP will be involved in teaching or coaching on topics that will improve both performance, safe participation and survival in extreme environments.