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Leveraging single nuclei expression signatures and assays of disease progression to explore mechanisms of prophylactic and therapeutic intervention targeting the inflammatory response in a mouse model of Parkinson Disease

Leveraging single nuclei expression signatures and assays of disease progression to explore mechanisms of prophylactic and therapeutic intervention targeting the inflammatory response in a mouse model of Parkinson Disease
利用单核表达特征和疾病进展分析来探索针对帕金森病小鼠模型炎症反应的预防和治疗干预机制
批准号：
457118
负责人：
Boyd Rachel J
金额：
$7.65万
依托单位：
The Johns Hopkins University School of Medicine (Baltimore, Maryland)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-10-01 至 2024-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=457118&lang=en
关键词：
Bioinformatics Disease Onset Histology Inflammatory Response Neurodegeneration Non-Steroidal Anti-Inflammatory Drugs Parkinson Disease Prophylatic Intervention Single-Nucleus Rna Sequencing Transcriptomics

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中文摘要
翻译
帕金森病(PD)是继阿尔茨海默病之后加拿大第二大最常见的神经退行性疾病，在全球范围内影响着1000多万人。帕金森病的特征是大脑黑质区域的神经元丢失。帕特
英文摘要
Parkinson disease (PD) follows Alzheimer disease as the second most common neurodegenerative disease in Canada and affects over 10 million people worldwide. PD is characterized by a loss of neurons in a region of the brain called the substantia nigra. Pat
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