Cellular and Metabolic Processes in Regional Adipose Tissue

区域脂肪组织的细胞和代谢过程

• 批准号: RGPIN-2020-06809
• 负责人: Santosa, Sylvia
• 金额: $ 2.91万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718523
• 关键词: Cellular; Metabolic; Processes; Regional; Adipose

Society has a preoccupation with fat. This preoccupation is far-reaching and extends from our concern with body fat to food and agriculture. For example in agriculture, there is a focus is on the amount and type of fat in dairy products and livestock. As a population or individual, we do not want to be too fat or too skinny. We are also fixated on how much fat we have and where we store it, whether it is around our stomachs or around our hips and thighs. The places in the body where fat is stored is different in males and females. We know that not all fat is equal and that fat behaves differently based on where and in whom fat is stored. For example, we know that fat stored in the upper body fat tissue releases more fat than in the lower body and that this release of fat is greater in males than in females. However, though we are preoccupied with fat as a society, we don't know much about the fat cell itself, the environment in which the fat cell lives, and how the fat cells interact with the rest of the body. The proposed program of research seeks to understand how fat cells are programmed to store the amount of fat that they do and how fat cell programming affects its surrounding tissue environment and biological systems. We also aim to see whether there are differences in how fat and fat cells behave in males vs females. To answer our questions we want to determine if early-life programming of the fat cell in males and females affects: 1) how the fat stored in muscle is used in excercise, 2) the communication between fat and muscle cells, 3) how fat produces hormones and uses acetyl CoA, a central molecule of metabolism. The findings from the proposed research program will contribute towards changing how we think about fat tissues and cells and its impact on biological systems. If we can understand why fat tissues and fat cells behave the way they do, we can use that information to target changes in their behaviour. This information would potentially benefit our society through impacting health, agriculture, and food science industries. For example, the information could be used to maintain muscle or improve quality of meat from livestock. The potential benefits of our findings are far reaching spanning from individuals to industry.

社会对肥胖有着浓厚的兴趣。这种关注是深远的，从我们对身体脂肪的关注延伸到食品和农业。例如，在农业中，重点是乳制品和牲畜中脂肪的数量和类型。作为一个群体或个人，我们不想太胖或太瘦。我们还关注我们有多少脂肪以及我们储存脂肪的地方，无论是在我们的腹部还是臀部和大腿周围。男性和女性体内储存脂肪的地方是不同的。我们知道，并非所有的脂肪都是平等的，脂肪的行为取决于脂肪储存在哪里和谁身上。例如，我们知道储存在上半身脂肪组织中的脂肪比下半身释放更多的脂肪，男性的脂肪释放量比女性大。然而，尽管我们关注的是脂肪作为一个社会，我们不知道很多关于脂肪细胞本身，脂肪细胞的生活环境，以及脂肪细胞如何与身体的其他部分相互作用。 拟议的研究计划旨在了解脂肪细胞是如何被编程以存储它们所做的脂肪量，以及脂肪细胞编程如何影响其周围的组织环境和生物系统。我们还旨在了解男性与女性的脂肪和脂肪细胞行为是否存在差异。 为了回答我们的问题，我们想确定男性和女性脂肪细胞的早期编程是否会影响： 1)储存在肌肉中的脂肪是如何在运动中使用的， 2)脂肪和肌肉细胞之间的交流， 3)脂肪是如何产生激素和使用乙酰辅酶A的，乙酰辅酶A是新陈代谢的核心分子。 拟议研究计划的发现将有助于改变我们对脂肪组织和细胞及其对生物系统影响的看法。如果我们能理解为什么脂肪组织和脂肪细胞的行为方式，我们就可以利用这些信息来改变它们的行为。这些信息可能会通过影响健康，农业和食品科学行业而使我们的社会受益。例如，这些信息可以用来保持肌肉或提高牲畜的肉的质量。我们的研究结果的潜在好处是深远的，从个人到行业。