A Microwave System for Medicinal Chemistry and Radiochemistry Research

侯、坎贝尔和江博士的研究项目将有机合成、放射化学、药物化学、计算化学和生物化学结合在一起，一直在寻找新的诊断和治疗工具。新的治疗工具和诊断工具的成功发现将大大改进疾病的预防、早期诊断和管理。如果疾病被更早地发现、更早地治疗和更有效地监测，许多人的生活质量将得到改善。它将导致医疗质量的提高和医疗系统负担的减轻。侯博士的研究重点是发现可用于正电子发射断层扫描(PET)癌症成像的氟-18标记分子显像剂，以及放射性氟化方法的开发。坎贝尔博士的研究小组致力于开发新的放射化学合成方法，并将其应用于新显像剂的开发。江博士的研究涉及合成从多肽和碳水化合物中提取的化合物，用于靶向癌症治疗。本申请中要求的微波反应器系统是一种多功能合成器，可以进行快速的微波辅助有机合成，是整个学术化学研究实验室和制药行业使用的标准设备。与使用油浴和热板的传统回流加热相比，它具有几个优点，包括提高产率，将反应时间从几天或几小时缩短到几分钟，并促进进入新的化学空间。它已成为合成有机化学、药物化学和放射化学中必不可少的工具，也是侯、坎贝尔和江博士开发治疗和诊断分子工具的研究计划中的关键元素。由所要求的设备支持的研究计划将在许多方面使加拿大受益。首先，这项研究将导致发现用于疾病预防、早期诊断和管理的成像探针。其次，无线电转换和成像示踪剂的新方法的发明将提高加拿大(无线电)制药业的竞争力。最后，参与建议研究项目的学生将接受关于最先进的微波辅助合成的深入培训，并将获得药物/显像剂合成和发现的全面知识和动手技能。这些设备，以及研究计划，将允许培训下一代科学家，以便更好地为在学术界或制药行业成功的职业生涯做准备。

The research programs of Drs. Hou, Campbell and Jiang have been searching for novel diagnostic and therapeutic tools by bringing together organic synthesis, radiochemistry, medicinal chemistry, computational chemistry and biochemistry. Successful discovery of novel therapeutic tools and diagnostic tools will significantly improve prevention, early diagnosis and management of diseases. The quality of life of many people will be improved if diseases are detected earlier, treated sooner, and monitored more effectively. It will lead to improved quality of health care and a reduced burden on the health care system. Dr. Hou's research focuses on the discovery of Fluorine-18 labelled molecular imaging agents for potential use in the imaging of cancer using Positron Emission Tomography (PET), and the development of radio-fluorination methods. Dr. Campbell's research group is focused on the development of new synthetic procedures for radiochemistry and applying them to the development of new imaging agents. Dr. Jiang's research involves the synthesis of compounds derived from peptides and carbohydrates for targeted cancer therapy. The microwave reactor system requested in this application is a versatile synthesizer that can perform rapid microwave assisted organic synthesis, and is a standard piece of equipment used throughout academic chemistry research labs and in the pharmaceutical industries. It offers several advantages including improved yield, shorter reaction times from days or hours down to minutes, and facilitates access to new chemical space as compared to conventional reflux heating using oil baths and hot plates. It has become an essential tool in synthetic organic chemistry, medicinal chemistry and radiochemistry and a key element in the research programs of Drs. Hou, Campbell and Jiang in the development of therapeutic and diagnostic molecular tools. The research programs supported by the requested equipment will benefit Canada in many ways. Firstly, the research would lead to the discovery of imaging probes for prevention, early diagnosis and management of diseases. Secondly, the invention of novel methods for radio-transformations and imaging tracers will enhance the competitivity of Canadian (radio)pharmaceutical industry. Lastly, the students who are involved in the proposed research programs will receive in-depth training on the most advanced microwave-assisted synthesis and will gain comprehensive knowledge and hands-on skills for drug/imaging agent synthesis and discovery. The equipment, along with the research programs, will allow for the training of next generation scientists to better prepare for a successful career in academia or pharmaceutical industry.