Development of Radio-Fluorination Methods and Novel Molecular Imaging Agents
放射性氟化方法和新型分子成像剂的发展
基本信息
- 批准号:RGPIN-2019-05098
- 负责人:
- 金额:$ 1.75万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Traditionally drug discovery is a lengthy, high-risk, and costly process, entrenched with a high degree of uncertainty that a drug will eventually succeed. Molecular imaging techniques allow noninvasive assessment of biochemical and biological processes in vivo. Molecular imaging has become indispensable in clinical use and is believed to hold promise for personalized medicine. Advances in molecular imaging technologies and imaging probes for humans and for small animals are extending the applications of imaging further into drug discovery and development, and have the potential to accelerate the process. However, the challenges of imaging agent discovery, e.g. limited radiochemical transformation methods available and a limited number of imaging agents being developed, have significantly restricted the potential of molecular imaging modalities in clinical use and drug discovery.
Our research group has a long term goal to develop novel and useful radiochemical transformations and application of those transformations to the challenge of preparing target molecules with biological significance. It further seeks to develop novel molecular imaging probes as tools to investigate biochemical and biological processes in vivo. In this proposal, we will describe our plans to address the above long term objectives by addressing the following more focused short term objectives in detail: (1) The use of the Mitsunobu reaction and Pd(0) catalyzed reactions for the development of late-stage stereospecific radio-fluorination methods, (2) the development of novel imaging agents targeting lysophosphatidic acid receptor 1 (LPA1), for the study of LPA1 related biological processes, (3) the development of in silico screening approaches and the discovery of novel imaging agents targeting prostate-specific membrane antigen.
A total of 12 HQP (2 PhD, 5 MSc and 5 undergraduate students) will be trained over the next 5 years. The above chemistry is anticipated to enrich the radiochemical tool box' and allow radiochemists greater access to target molecules that has previously not or been difficult to access synthetically. The novel imaging agents discovered and the new approaches developed in this fundamental research program will be powerful tools to allow the study and understanding of important biochemical and biological processes in vivo, which will be pursued in future CIHR grant application.
传统上,药物发现是一个漫长、高风险和昂贵的过程,药物最终能否成功存在高度的不确定性。分子成像技术允许无创评估体内生化和生物过程。分子成像在临床应用中已成为不可或缺的,并被认为有望实现个性化医疗。分子成像技术和用于人类和小动物的成像探针的进步正在将成像的应用进一步扩展到药物发现和开发中,并有可能加速这一进程。然而,显像剂发现的挑战,例如可用的放射化学转化方法有限,正在开发的显像剂数量有限,极大地限制了分子成像方式在临床应用和药物发现中的潜力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hou, Jinqiang其他文献
Development of Candidates for Positron Emission Tomography (PET) Imaging of Ghrelin Receptor in Disease: Design, Synthesis, and Evaluation of Fluorine-Bearing Quinazolinone Derivatives
- DOI:
10.1021/acs.jmedchem.7b01754 - 发表时间:
2018-02-08 - 期刊:
- 影响因子:7.3
- 作者:
Hou, Jinqiang;Kovacs, Michael S.;Luyt, Leonard G. - 通讯作者:
Luyt, Leonard G.
Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase
- DOI:
10.1021/ml400145x - 发表时间:
2013-08-01 - 期刊:
- 影响因子:4.2
- 作者:
Hou, Jinqiang;Teo, Theodosia;Wang, Shudong - 通讯作者:
Wang, Shudong
Hou, Jinqiang的其他文献
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{{ truncateString('Hou, Jinqiang', 18)}}的其他基金
Development of Radio-Fluorination Methods and Novel Molecular Imaging Agents
放射性氟化方法和新型分子成像剂的发展
- 批准号:
RGPIN-2019-05098 - 财政年份:2022
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Development of Radio-Fluorination Methods and Novel Molecular Imaging Agents
放射性氟化方法和新型分子成像剂的发展
- 批准号:
RGPIN-2019-05098 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
A Microwave System for Medicinal Chemistry and Radiochemistry Research
用于药物化学和放射化学研究的微波系统
- 批准号:
RTI-2021-00696 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Research Tools and Instruments
Development of Radio-Fluorination Methods and Novel Molecular Imaging Agents
放射性氟化方法和新型分子成像剂的发展
- 批准号:
RGPIN-2019-05098 - 财政年份:2019
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Development of Radio-Fluorination Methods and Novel Molecular Imaging Agents
放射性氟化方法和新型分子成像剂的发展
- 批准号:
DGECR-2019-00204 - 财政年份:2019
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Launch Supplement
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