Genetic variability and trans-generational effects on production in dairy cattle

奶牛生产的遗传变异和跨代效应

基本信息

  • 批准号:
    515616-2019
  • 负责人:
  • 金额:
    $ 2.26万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Research and Development Grants
  • 财政年份:
    2021
  • 资助国家:
    加拿大
  • 起止时间:
    2021-01-01 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

A new phenomenon has been discovered in mammals over the last 2 decades, the influence of the mother's metabolic environment on the phenotype of the offspring. Although this has been initially observed in epidemiological survey in humans (Barker Hypothesis) it has been extended to all mammals studied so far including sheep and cows. The metabolic condition of both the mother and the father can leave functional trans-generational effects that will affect the health status and production of the following generation and in some conditions of the subsequent generation. The best example outside of the Dutch famine is the fat diet applied to mice which program obesity even on a normal diet. In bovines, it has been shown that feed restriction starting before conception has a direct influence on follicle count in the daughter. This is important since follicle count has a direct link with fertility in cows and in humans. Therefore, it can be postulated that the insemination of cows during a period of high lactation often associated with a negative energy balance may have programmed the daughter with a diminished ovarian reserve and lower fertility and lower production. Currently the magnitudes of such trans-generational effects in dairy cattle in Canada are not known are. It is proposed to use milk recording data on production and feed, together with health event data to estimate such trans-generational effects on production traits and hence determine whether these need to be accounted for in genetic evaluation systems and whether they could be incorporated into farm-management advising.
在过去的20年里,在哺乳动物中发现了一种新的现象,即母亲的代谢环境对后代表型的影响。虽然这最初是在人类流行病学调查(巴克假说)中观察到的,但它已经扩展到迄今研究的所有哺乳动物,包括绵羊和牛。母亲和父亲的代谢状况都会产生跨代影响,这将影响下一代的健康状况和生产,在下一代的某些情况下也会受到影响。除了荷兰饥荒,最好的例子是应用于老鼠的脂肪饮食,即使在正常饮食的情况下,它们也会编程肥胖。在牛身上,已经表明在受孕前开始限制饲料对子牛的卵泡数量有直接影响。这一点很重要,因为毛囊数量与奶牛和人类的生育能力有直接联系。因此,可以推测,在高哺乳期给奶牛授精,通常伴随着负能量平衡,可能是导致卵巢储备减少、生育能力和产奶量下降的女儿的程序。目前,加拿大奶牛的这种跨代影响的程度尚不清楚。建议使用关于生产和饲料的牛奶记录数据以及健康事件数据来估计这种对生产特性的跨代影响,从而确定是否需要在遗传评估系统中考虑这些影响,以及是否可以将其纳入农场管理建议。

项目成果

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Cue, Roger其他文献

Culling from the actors' perspectives-Decision-making criteria for culling in Quebec dairy herds enrolled in a veterinary preventive medicine program
  • DOI:
    10.1016/j.prevetmed.2017.09.015
  • 发表时间:
    2017-12-01
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Haine, Denis;Cue, Roger;Dubuc, Jocelyn
  • 通讯作者:
    Dubuc, Jocelyn

Cue, Roger的其他文献

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{{ truncateString('Cue, Roger', 18)}}的其他基金

Genetic variability and trans-generational effects on production in dairy cattle
奶牛生产的遗传变异和跨代效应
  • 批准号:
    515616-2019
  • 财政年份:
    2020
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants
Genetic variability and trans-generational effects on production in dairy cattle
奶牛生产的遗传变异和跨代效应
  • 批准号:
    515616-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants
Genetic variability of health traits in dairy cattle
奶牛健康性状的遗传变异
  • 批准号:
    306212-2004
  • 财政年份:
    2006
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants
Genetic variability of health traits in dairy cattle
奶牛健康性状的遗传变异
  • 批准号:
    306212-2004
  • 财政年份:
    2004
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants
A bio-economic model of the dairy enterprise
乳品企业的生物经济模型
  • 批准号:
    195830-1996
  • 财政年份:
    1996
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Industrially Oriented Research Grants
Animal model parameter estimation in dairy cattle
奶牛动物模型参数估计
  • 批准号:
    117437-1991
  • 财政年份:
    1993
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants - Government (H)
Animal model parameter estimation in dairy cattle
奶牛动物模型参数估计
  • 批准号:
    117437-1991
  • 财政年份:
    1992
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants - Government (H)
Animal model parameter estimation in dairy cattle
奶牛动物模型参数估计
  • 批准号:
    117437-1991
  • 财政年份:
    1991
  • 资助金额:
    $ 2.26万
  • 项目类别:
    Collaborative Research and Development Grants - Government (H)

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奶牛生产的遗传变异和跨代效应
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    Collaborative Research and Development Grants
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