Genetic variability and trans-generational effects on production in dairy cattle

奶牛生产的遗传变异和跨代效应

• 批准号: 515616-2019
• 负责人: Cue, Roger
• 金额: $ 2.26万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699577
• 关键词: Genetic; variability; trans; generational; effects

A new phenomenon has been discovered in mammals over the last 2 decades, the influence of the mother's metabolic environment on the phenotype of the offspring. Although this has been initially observed in epidemiological survey in humans (Barker Hypothesis) it has been extended to all mammals studied so far including sheep and cows. The metabolic condition of both the mother and the father can leave functional trans-generational effects that will affect the health status and production of the following generation and in some conditions of the subsequent generation. The best example outside of the Dutch famine is the fat diet applied to mice which program obesity even on a normal diet. In bovines, it has been shown that feed restriction starting before conception has a direct influence on follicle count in the daughter. This is important since follicle count has a direct link with fertility in cows and in humans. Therefore, it can be postulated that the insemination of cows during a period of high lactation often associated with a negative energy balance may have programmed the daughter with a diminished ovarian reserve and lower fertility and lower production. Currently the magnitudes of such trans-generational effects in dairy cattle in Canada are not known are. It is proposed to use milk recording data on production and feed, together with health event data to estimate such trans-generational effects on production traits and hence determine whether these need to be accounted for in genetic evaluation systems and whether they could be incorporated into farm-management advising.

在过去的20年里，在哺乳动物中发现了一种新的现象，即母亲的代谢环境对后代表型的影响。虽然这最初是在人类的流行病学调查中观察到的（巴克假说），但它已扩展到迄今为止研究的所有哺乳动物，包括绵羊和奶牛。母亲和父亲的代谢状况可能会产生功能性的代际效应，影响下一代的健康状况和生产，在某些情况下还会影响下一代。除了荷兰饥荒之外，最好的例子是将脂肪饮食应用于小鼠，即使在正常饮食下也会导致肥胖。在牛中，已经证明在受孕前开始的限饲对子代的卵泡计数有直接影响。这一点很重要，因为卵泡计数与奶牛和人类的生育能力有直接联系。因此，可以假设，在通常与负能量平衡相关的高泌乳期对奶牛进行授精，可能使女儿的卵巢储备减少，生育力降低，产量降低。 目前，加拿大奶牛这种跨代影响的程度尚不清楚。建议使用生产和饲料的牛奶记录数据，以及健康事件数据来估计这种生产性状的跨代影响，从而确定这些是否需要在遗传评估系统中考虑，以及它们是否可以纳入农场管理建议。