Oral Thin Film Delivery Vehicles

尽管已经开发了许多针对SARS-CoV-2的疫苗，并已被证明非常有效，但通过肌肉内注射给药的传统疫苗昂贵、耗时且操作复杂。此外，其令人不快的患者体验是疫苗犹豫的重要驱动因素，延长了大流行的恢复过程。该项目旨在开发一种强大、方便和易于管理的mrna疫苗递送系统，避免皮下注射和疫苗接种过程中对训练有素的卫生保健专业人员的需求。该系统将使用在口腔中迅速溶解（几秒钟内）的薄聚合物条，并装载含有病毒抗原mRNA编码的脂质纳米颗粒，提供一种替代载体，可以轻松方便地将精确剂量的疫苗输送到口腔粘膜。已经证明，舌下液体形式的疫苗在产生针对多种感染原的免疫反应方面是有效的。该项目将把这些成果推进到薄膜平台，使疫苗接种能够以操作简单的方式进行，并使全球疫苗接种的步伐大大加快。

Although a number of vaccines for SARS-CoV-2 have been developed and have proven highly effective, administration of conventional vaccines via intra-muscular injection is expensive, time-consuming, and operationally complex. Additionally, its unpleasant patient experience is a significant driver of vaccine hesitency, prolonging the pandemic recovery process. This project aims to develop a robust, convenient, and easily administered delivery system for mRNA-based vaccines, avoiding sub-cutaneous injection and the requirement for trained healthcare professionals in the vaccination process. This system will use thin polymer strips that dissolve rapidly (within several seconds) in the mouth and are loaded with lipid nanoparticles that contain the mRNA coding for viral antigens, providing an alternative vehicle that can easily and conveniently deliver a precise dose of vaccine to the oral mucosae. It has already been shown that sub-lingual vaccine delivery in liquid form is effective in producing an immune response to a variety of infectious agents. This project will advance these results to the thin-film platform, allowing vaccinations to be carried out in an operationally simple manner, and enabling the pace of global vaccination to dramatically increase.