Oral Thin Film Delivery Vehicles

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Although a number of vaccines for SARS-CoV-2 have been developed and have proven highly effective, administration of conventional vaccines via intra-muscular injection is expensive, time-consuming, and operationally complex. Additionally, its unpleasant patient experience is a significant driver of vaccine hesitency, prolonging the pandemic recovery process. This project aims to develop a robust, convenient, and easily administered delivery system for mRNA-based vaccines, avoiding sub-cutaneous injection and the requirement for trained healthcare professionals in the vaccination process. This system will use thin polymer strips that dissolve rapidly (within several seconds) in the mouth and are loaded with lipid nanoparticles that contain the mRNA coding for viral antigens, providing an alternative vehicle that can easily and conveniently deliver a precise dose of vaccine to the oral mucosae. It has already been shown that sub-lingual vaccine delivery in liquid form is effective in producing an immune response to a variety of infectious agents. This project will advance these results to the thin-film platform, allowing vaccinations to be carried out in an operationally simple manner, and enabling the pace of global vaccination to dramatically increase.