Identification of disease-associated immune cells and inflammatory cytokines in a MATR3 S85C knock-in mouse model of amyotrophic lateral sclerosis

肌萎缩侧索硬化症 MATR3 S85C 敲入小鼠模型中疾病相关免疫细胞和炎症细胞因子的鉴定

• 批准号: 466605
• 负责人: Lee Jooyun
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466605&lang=en
• 关键词: Amyotrophic Lateral Sclerosis; Cytokines; Immune System; Knock-In Mouse Model; Matr3; Neurodegeneration; Neuroinflammation; Single Cell Transcriptomic Profiling

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves the gradual loss of motor neurons, leading to paralysis and death. Although the cause of ALS is unknown, neuroinflammation has been proposed as a possible mechanism leading t

肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，涉及运动神经元的逐渐丧失，导致瘫痪和死亡。虽然ALS的病因尚不清楚，但神经炎症已被认为是导致ALS的可能机制。