Molecular pathogenesis of BRCA1-associated and triple-negative breast cancer: mechanism of tissue specificity and identification and characterization of cooperating tumorigenic pathways.

BRCA1 相关和三阴性乳腺癌的分子发病机制：组织特异性机制以及协同致瘤途径的识别和表征。

• 批准号: 206486
• 负责人: Cescon David W
• 金额: $ 1.46万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2013-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=206486&lang=en
• 关键词: Animal Models Of Cancer; Brca1 Associated Cancer; Cancer; Medical Oncology; Oncogenes And Tumor Suppressor Genes; Rnai

Breast cancer affects almost 23 000 Canadian women each year, and remains a major cause of death. Five percent all breast cancers, and 80% of inherited cases, are caused by mutations in the BRCA1 gene. Women who carry these mutations are also at high risk

乳腺癌每年影响近23000名加拿大妇女，并且仍然是主要的死亡原因。5%的乳腺癌和80%的遗传病例是由BRCA1基因突变引起的。携带这些突变的女性也有很高的风险。