Bioinformatics Algorithms
Bioinformatics Algorithms
批准号:
CRC-2017-00215
负责人:
Hallett, Michael
金额:
$14.57万
依托单位:
依托单位国家:
加拿大
项目类别:
Canada Research Chairs
财政年份:
2021
资助国家:
加拿大
项目状态:
已结题
起止时间:
2021-01-01 至 2022-12-31
中文摘要
特征是一种现代类型的生物标志物,起源于系统生物学,其中高通量技术提供了样本的全基因组测量。它们比单一生物标志物方法有许多优点,并且已经在临床和研究环境中得到了应用。本计算生物学提案将改进与签名相关的方法学。我们的方法使用概率图形模型来构建“转录特征网络”,该网络捕捉到分子过程紧密相连并依赖于许多细胞信号的事实。利用我们的高通量机器人设备,我们将为白色念珠菌建立一个网络,这是一种可以与人类共生或致病的生物。
英文摘要
Signatures are a modern type of biomarker arising from systems biology where high-throughput technologies provide genome-wide measurements of samples. They have many advantages over single biomarker approaches, and have already found utility in clinical and research contexts. This computational biology proposal will improve methodology related to signatures. Our approach uses probabilistic graphical models to build ¿transcriptional signature networks¿ that capture the fact that molecular processes are tightly inter-connected and dependent on many cellular signals. Using our high-throughput robotics facility, we will build a network for C albicans, an organism that can be commensal or pathogenic for humans.
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Probabilistic approaches to optimize synthetic organisms
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批准号:RGPIN-2018-05085
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.03万
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财政年份:2020
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负责人:Hallett, Michael
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依托单位:
Bioinformatics algorithms
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批准号:CRC-2017-00215
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项目类别:Canada Research Chairs
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资助金额:$14.57万
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财政年份:2020
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负责人:Hallett, Michael
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依托单位:
Bioinformatics algorithms
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批准号:CRC-2017-00215
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项目类别:Canada Research Chairs
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资助金额:$14.57万
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财政年份:2019
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负责人:Hallett, Michael
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依托单位:
Probabilistic approaches to optimize synthetic organisms
-
批准号:RGPIN-2018-05085
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$5.03万
-
财政年份:2019
-
负责人:Hallett, Michael
-
依托单位:
Probabilistic approaches to optimize synthetic organisms
-
批准号:RGPIN-2018-05085
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$5.03万
-
财政年份:2018
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负责人:Hallett, Michael
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依托单位:
Bioinformatics algorithms
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批准号:CRC-2017-00215
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项目类别:Canada Research Chairs
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资助金额:$14.57万
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财政年份:2018
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负责人:Hallett, Michael
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依托单位:
Bioinformatics algorithms
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批准号:CRC-2017-00215
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2017
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负责人:Hallett, Michael
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依托单位:
Signature analysis tools for the life sciences
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批准号:238978-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2015
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负责人:Hallett, Michael
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依托单位:
Signature analysis tools for the life sciences
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批准号:238978-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2014
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负责人:Hallett, Michael
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依托单位:
Signature analysis tools for the life sciences
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批准号:238978-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2013
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负责人:Hallett, Michael
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依托单位:
Signature analysis tools for the life sciences
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批准号:238978-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2012
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负责人:Hallett, Michael
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依托单位:
Signature analysis tools for the life sciences
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批准号:238978-2011
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.91万
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财政年份:2011
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负责人:Hallett, Michael
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依托单位:
Molecular signatures of synergy
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批准号:238978-2010
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2010
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负责人:Hallett, Michael
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依托单位:
Tools for exploring biological networks
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批准号:238978-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2009
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负责人:Hallett, Michael
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依托单位:
Tools for exploring biological networks
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批准号:238978-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2008
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负责人:Hallett, Michael
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依托单位:
Tools for exploring biological networks
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批准号:238978-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2007
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负责人:Hallett, Michael
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依托单位:
Tools for exploring biological networks
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批准号:238978-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2006
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负责人:Hallett, Michael
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依托单位:
Tools for exploring biological networks
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批准号:238978-2005
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2005
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负责人:Hallett, Michael
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依托单位:
Genomic evolution and gene expression
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批准号:238978-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2003
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负责人:Hallett, Michael
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依托单位:
Genomic evolution and gene expression
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批准号:238978-2001
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2002
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负责人:Hallett, Michael
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依托单位:
海外基金