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Molecular mechanisms underlying inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland

Molecular mechanisms underlying inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland
纽芬兰遗传性致心律失常性右室心肌病的分子机制
批准号：
462216
负责人：
Esseltine Jessica L
金额：
$61.02万
依托单位：
Memorial University of Newfoundland
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-03-01 至 2027-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462216&lang=en
关键词：
3d Engineered Heart Tissue Arrhythmia Arrhythmogenic Right Ventricular Cardiomyopathy Cardiac Fibroblasts Cardiomyocytes Crispr-Cas9 Fibrosis Induced Pluripotent Stem Cells Patient-Derived Samples Tmem43

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英文摘要
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart disease that can cause sudden death as its first symptom. It tragically shortens the lives of healthy young people, with men affected worse than women. 50% of ARVC men will die by age 40, a
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