Neurogenomics

神经基因组学

• 批准号: CRC-2019-00145
• 负责人: Wright, Galen
• 金额: $ 8.74万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730650
• 关键词: Neurogenomics

DNA encodes hereditary information in living organisms ¿ in order to ensure that this material conveys genetic data correctly, it is essential that damage that occurs to DNA is accurately repaired. Since the brain consumes large amounts of energy, the cells in this tissue are exposed to a substantial amount of damage, which is repaired via complex biological pathways. Dr. Wright¿s research program will use advanced computational approaches to study high throughput genomic data to uncover novel mechanistic insights into the genes and pathways involved in DNA damage response and repair in the brain.

DNA编码生物体中的遗传信息，为了确保这种材料正确传递遗传数据，必须准确修复DNA发生的损伤。由于大脑消耗大量能量，该组织中的细胞暴露于大量损伤，这些损伤通过复杂的生物途径进行修复。赖特博士的研究计划将使用先进的计算方法来研究高通量的基因组数据，以揭示新的机制见解的基因和途径参与DNA损伤反应和修复的大脑。