NEUROGENOMICS CORE
神经基因组学核心
基本信息
- 批准号:10455677
- 负责人:
- 金额:$ 8.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-23 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAnimal ModelAnimalsApplications GrantsArchitectureAreaAwardBehavior DisordersBioinformaticsBiologicalBiological AssayBiomedical ResearchCancer CenterCell LineCellsChromatinComplementComplexComputer AnalysisConsultationsDNADNA Modification ProcessDNA SequenceDNA analysisDataData AnalysesDiagnosisDiseaseEnsureEvaluationFamiliarityFeasibility StudiesFoundationsFundingFutureGene ExpressionGenesGeneticGenomicsGenotypeGoalsGrantHigh Performance ComputingHumanHuman GeneticsHuman ResourcesIndividualIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInvestigationMeasuresMethylationModelingNeurosciencesNucleic Acid Regulatory SequencesPatientsPharmaceutical PreparationsPilot ProjectsPopulation GeneticsPostdoctoral FellowProcessQuality ControlRNARNA SequencesResearchResearch DesignResearch PersonnelRoleServicesSolidStructureTNFRSF5 geneTechnologyTimeTissuesTrainingVariantXCL1 geneautism spectrum disorderbasebrain malformationcollegecomputerized data processingcostcost effectivedesignepigenomeepigenomicsexomeexome sequencingexperienceexperimental studyflexibilityfunctional genomicsgenome sequencinggenome-widegenomic datahuman subjectimprovedinduced pluripotent stem cellinnovationinnovative technologiesinterestlarge datasetsmembernerve stem cellneurogenomicsnew technologynext generation sequencingoperationprogramssecondary analysissingle cell technologysingle-cell RNA sequencingskillsstudent trainingtranscriptomicsvoucherwhole genome
项目摘要
PROJECT SUMMARY/ABSTRACT – NEUROGENOMICS CORE
Neurogenomics research, including analysis of DNA, RNA and the epigenome, consisting of investigation of
chromatin and methylation, is increasingly important in studies of intellectual and developmental disabilities
(IDDs). For example, neurogenomics analysis can identify the cause of human IDDs as well as determine the
mechanism by which genes are regulated in animal or cell-based models. The Neurogenomics (NGEN) Core
provides standard and innovative genomic assays that range from genotyping of DNA variants in human
subjects through single cell RNA-sequencing or evaluation of accessible chromatin in neural progenitor cells.
The NCEI with the NGEN Core will establish spatial transcriptomic technology, making it possible to investigate
gene expression in the context of tissue architecture. Further, the NGEN Core provides computational and
bioinformatic analysis of large datasets that emerge from next-generation sequencing (NGS) experiments and
will train students and postdoctoral fellows. The NGEN core is flexible to relinquish old services that are no
longer utilized or cost effective, to implement innovative services that will enhance IDD research and discovery.
The team consists of a Director and Associate Director with complementary expertise in human genetics,
functional genomics and epigenomics. The Operations Directors have hands-on roles in implementing and
establishing new technologies or bioinformatic services that are performed by senior technical staff. The
NGEN Core has an advisory committee needed to ensure optimal service and to help decide which services to
offer in the Core. The NGEN Core Components are part of established shared facilities at Einstein that also
has oversite from the Cancer Center and College. One of the challenges in performing genomics research is
how to choose among many different assays that are available. The NGEN Core provides guidance to IDDRC
investigators in a prioritized manner, from study design, to experimental optimization to bioinformatic analysis.
For this, the Directors meet with individual investigators to provide guidance in helping to choose assays that
are best suited for their particular research question. Members of the IDDRC will receive prioritized access to
NGEN Core services and personalized consultation. The IDDRC Pilot Award and Voucher program is also
available through the ADM Core on a competitive basis, making it possible for investigators to initiate
neurogenomics projects even if current grant funding is limited. Through this facilitated availability of a wide
range of services and innovative technologies involving critical aspects of genomic analysis, the NGEN core is
an essential component of the IDDRC.
项目摘要/摘要 – 神经基因组学核心
神经基因组学研究,包括 DNA、RNA 和表观基因组的分析,包括对
染色质和甲基化在智力和发育障碍的研究中变得越来越重要
(国际长途电话)。例如,神经基因组学分析可以识别人类 IDD 的原因并确定
在动物或细胞模型中调节基因的机制。神经基因组学 (NGEN) 核心
提供标准和创新的基因组检测,范围包括人类 DNA 变异的基因分型
通过单细胞 RNA 测序或评估神经祖细胞中可接近的染色质来研究受试者。
NCEI 与 NGEN Core 将建立空间转录组技术,使研究成为可能
组织结构背景下的基因表达。此外,NGEN Core 还提供计算和
对下一代测序 (NGS) 实验产生的大型数据集进行生物信息分析
将培训学生和博士后研究员。 NGEN 核心可以灵活地放弃不需要的旧服务
延长使用时间或具有成本效益,以实施创新服务,从而加强 IDD 研究和发现。
该团队由一名主任和副主任组成,他们在人类遗传学方面具有互补的专业知识,
功能基因组学和表观基因组学。运营总监在实施和
建立由高级技术人员执行的新技术或生物信息服务。这
NGEN Core 设有一个咨询委员会,以确保提供最佳服务并帮助决定提供哪些服务
核心报价。 NGEN 核心组件是 Einstein 已建立的共享设施的一部分
癌症中心和学院有驻场。进行基因组学研究的挑战之一是
如何在许多可用的不同检测中进行选择。 NGEN 核心为 IDDRC 提供指导
从研究设计到实验优化再到生物信息分析,研究人员以优先顺序进行。
为此,董事们与个别研究人员会面,提供指导,帮助选择适合的检测方法
最适合他们特定的研究问题。 IDDRC 成员将优先获得
NGEN 核心服务和个性化咨询。 IDDRC 试点奖励和优惠券计划还
通过 ADM Core 在竞争的基础上提供,使研究人员能够启动
即使当前的拨款资金有限,神经基因组学项目也会开展。通过这种方式,可以方便地获得广泛的
NGEN 的核心是涉及基因组分析关键方面的一系列服务和创新技术
IDDRC 的重要组成部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BERNICE E MORROW其他文献
BERNICE E MORROW的其他文献
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{{ truncateString('BERNICE E MORROW', 18)}}的其他基金
Molecular pathogenesis of congenital heart disease mediated by neural crest and second heart field cells
神经嵴和第二心野细胞介导先天性心脏病的分子发病机制
- 批准号:
10621288 - 财政年份:2022
- 资助金额:
$ 8.55万 - 项目类别:
Genetic modifiers of congenital heart disease in 22q11.2 deletion syndrome
22q11.2缺失综合征先天性心脏病的遗传修饰
- 批准号:
10373375 - 财政年份:2022
- 资助金额:
$ 8.55万 - 项目类别:
Genetic modifiers of congenital heart disease in 22q11.2 deletion syndrome
22q11.2缺失综合征先天性心脏病的遗传修饰
- 批准号:
10553279 - 财政年份:2022
- 资助金额:
$ 8.55万 - 项目类别:
Molecular pathogenesis of congenital heart disease mediated by neural crest and second heart field cells
神经嵴和第二心野细胞介导先天性心脏病的分子发病机制
- 批准号:
10435713 - 财政年份:2022
- 资助金额:
$ 8.55万 - 项目类别:
Molecular and cellular mechanisms in cardiac outflow tract formation and defects
心脏流出道形成和缺陷的分子和细胞机制
- 批准号:
10289982 - 财政年份:2021
- 资助金额:
$ 8.55万 - 项目类别:
Molecular and cellular mechanisms in cardiac outflow tract formation and defects
心脏流出道形成和缺陷的分子和细胞机制
- 批准号:
10471433 - 财政年份:2021
- 资助金额:
$ 8.55万 - 项目类别:
Cell fate choices by Tbx1 in forming the mammalian heart
Tbx1 在形成哺乳动物心脏过程中的细胞命运选择
- 批准号:
10615781 - 财政年份:2020
- 资助金额:
$ 8.55万 - 项目类别:
Cell fate choices by Tbx1 in forming the mammalian heart
Tbx1 在形成哺乳动物心脏过程中的细胞命运选择
- 批准号:
10242828 - 财政年份:2020
- 资助金额:
$ 8.55万 - 项目类别:
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