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Targeting methyl-CpG-binding domain protein 2 (Mbd2) towards the development of next generation precision Epi-therapies against metastatic breast cancer

Targeting methyl-CpG-binding domain protein 2 (Mbd2) towards the development of next generation precision Epi-therapies against metastatic breast cancer
靶向甲基 CpG 结合域蛋白 2 (Mbd2)，开发针对转移性乳腺癌的下一代精准外延疗法
批准号：
464539
负责人：
Rabbani Shafaat A
金额：
$7.29万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-03-01 至 2023-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=464539&lang=en
关键词：
Breast Cancer Dna Methylation Mouse Models Transgenic Mice Tumour Metastasis

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中文摘要
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英文摘要
Breast cancer metastasis to distant organs in general and to the skeleton in particular are a major cause of cancer associated morbidity and mortality. These patients are generally in advanced stages when no effective therapies are available. Cancer initi
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Role of methyl-CpG-binding domain protein 2 (Mbd2) in breast cancer development, progression and metastasis
Targeting methyl-CpG-binding domain protein 2 (Mbd2) towards the development of next generation precision Epi-therapies against metastatic breast cancer
Urokinase plasminogen activator (uPA) and its receptor (uPAR) interaction in tumor microenvironment, therapeutic implications
DNA demethylation blockers; novel preventive and therapeutic approach to breast cancer development, progression and metastasis
  • 批准号：
    279668
  • 项目类别：
    Operating Grants
  • 资助金额：
    $58.14万
  • 财政年份：
    2013
  • 负责人：
    Rabbani Shafaat A
  • 依托单位：
    McGill University
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