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Development of LNP/mRNA systems for direct transfection and generation of functional Chimeric Antigen Receptor (CAR) T-cells in-vivo for treatment of blood and other cancer cell types

Development of LNP/mRNA systems for direct transfection and generation of functional Chimeric Antigen Receptor (CAR) T-cells in-vivo for treatment of blood and other cancer cell types
开发 LNP/mRNA 系统,用于在体内直接转染和生成功能性嵌合抗原受体 (CAR) T 细胞,用于治疗血液和其他癌细胞类型
批准号:
463373
负责人:
Cullis Pieter R
金额:
$62.42万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-03-01 至 2027-03-01

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中文摘要
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英文摘要
Chimeric Antigen Receptor (CAR) T cell therapy is relatively new and exciting form of cancer therapy which uses a patients own re-programmed immune cells to specifically target and destroy cancer cells. In this treatment, T cells (a type of immune cell) a
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Rational Design of Lipid Nanoparticle Systems for mRNA Delivery
  • 批准号:
    478978
  • 项目类别:
    Operating Grants
  • 资助金额:
    $78.86万
  • 财政年份:
    2023
  • 负责人:
    Cullis Pieter R
  • 依托单位:
Newly Optimized LNP Systems for Genetic drugs and Gene therapy in Neurological diseases
  • 批准号:
    469979
  • 项目类别:
    Operating Grants
  • 资助金额:
    $77.03万
  • 财政年份:
    2022
  • 负责人:
    Cullis Pieter R
  • 依托单位:
Liver as a bioreactor for robust production of SARS-CoV-2 neutralizing antibodies
  • 批准号:
    429662
  • 项目类别:
    Operating Grants
  • 资助金额:
    $17.3万
  • 财政年份:
    2020
  • 负责人:
    Cullis Pieter R
  • 依托单位:
Lipid nanomedicines for health and disease
  • 批准号:
    334137
  • 项目类别:
    Operating Grants
  • 资助金额:
    $154.56万
  • 财政年份:
    2015
  • 负责人:
    Cullis Pieter R
  • 依托单位:
海外基金