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Using LIBRA-seq to identify broadly-reactive influenza antibodies in human respiratory tissues for translation into novel monoclonal therapeutics

Using LIBRA-seq to identify broadly-reactive influenza antibodies in human respiratory tissues for translation into novel monoclonal therapeutics
使用 LIBRA-seq 识别人类呼吸道组织中广泛反应的流感抗体，以转化为新型单克隆疗法
批准号：
471279
负责人：
McGrath Joshua J
金额：
$10.2万
依托单位：
Weill Cornell Medical College (New York, NY)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=471279&lang=en
关键词：
Antibodies Influenza Lung Lymph Node Memory B Cells Pediatric Tonsils

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Despite being identified 90 years ago, influenza remains one of the most dangerous respiratory viruses worldwide. Each year, circulating influenza strains infect and kill over 400 000 people. In addition, unique strains occasionally jump from animals (pig
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Using LIBRA-seq to identify broadly-reactive influenza antibodies in human respiratory tissues for translation into novel monoclonal therapeutics
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