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Roles of SPARC against muscle atrophy, sarcopenia and age-related metabolic disorders.

Roles of SPARC against muscle atrophy, sarcopenia and age-related metabolic disorders.
SPARC 在对抗肌肉萎缩、肌肉减少症和年龄相关代谢紊乱方面的作用。
批准号：
472283
负责人：
St-Amand Jonny
金额：
$7.29万
依托单位：
Centre hospitalier de l'Universit Laval (Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-09-01 至 2023-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=472283&lang=en
关键词：
Age-Related Diseases Disease Prevention Metabolic Diseases Molecular Mechanisms Muscle Atrophy Physical Exercise Sparc Transgenic Mice

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英文摘要
Sarcopenia represents a loss of muscle associated to aging. Exercise reverses sarcopenia and improves age-related diseases. We have shown that the exercise-induced gene SPARC modulates muscle differentiation, and Sparc overexpression mimics exercise effec
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Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria
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