Biophysical studies of uncoating and encapsidation in Picornaviruses

小核糖核酸病毒脱壳和衣壳化的生物物理研究

• 批准号: 468501
• 负责人: Strauss Mike
• 金额: $ 62.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468501&lang=en
• 关键词: Assembly; Cell Entry; Cryo-Electron Microscopy; Encapsidation; Genome Packaging; Picornavirus; Poliovirus; Uncoating

For viruses to be infectious, they need to be able to pass their genetic material into the cell so that more viruses can be made. This is not a simple task for picornaviruses like poliovirus, because the RNA genome is heavily charged and needs to pass thr

为了使病毒具有传染性，它们需要能够将它们的遗传物质传递到细胞中，以便制造更多的病毒。对于像脊髓灰质炎病毒这样的小核糖核酸病毒来说，这不是一项简单的任务，因为RNA基因组携带大量电荷，需要通过它们