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The structural biology of the RAF kinase family in RAS-ERK pathway signaling

The structural biology of the RAF kinase family in RAS-ERK pathway signaling
RAS-ERK 通路信号传导中 RAF 激酶家族的结构生物学
批准号:
468744
负责人:
Sicheri Frank
金额:
$78.86万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-09-01 至 2027-09-01

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中文摘要
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英文摘要
This proposal is focused on understanding how the RAF family kinases function. Protein kinases modify other proteins by addition of a small phosphate tag. The RAF family consists of five members, three of which (ARAF, BRAF and CRAF) can add phosphate to o
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Structure-function analysis of the eukaryotic protein kinases Bud32 and Aurora A and their roles in tRNA modification and mitotic entry
  • 批准号:
    443402
  • 项目类别:
    Operating Grants
  • 资助金额:
    $80.81万
  • 财政年份:
    2021
  • 负责人:
    Sicheri Frank
  • 依托单位:
Induced proximity therapeutics for the difficult-to-drug RAS and RAF oncoproteins
  • 批准号:
    452119
  • 项目类别:
    Operating Grants
  • 资助金额:
    $94.77万
  • 财政年份:
    2021
  • 负责人:
    Sicheri Frank
  • 依托单位:
CRC Tier 1
  • 批准号:
    364796
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2016
  • 负责人:
    Sicheri Frank
  • 依托单位:
Structural Principles of Signal Transduction
  • 批准号:
    312638
  • 项目类别:
    Operating Grants
  • 资助金额:
    $343.46万
  • 财政年份:
    2014
  • 负责人:
    Sicheri Frank
  • 依托单位:
海外基金