Systematic identification of synthetic interactions in bacteria towards the next-generation of antibiotics

系统鉴定细菌与下一代抗生素的合成相互作用

• 批准号: 468567
• 负责人: Côt Jean-Philippe
• 金额: $ 61.3万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468567&lang=en
• 关键词: Antibiotic Discovery; Bacteriology; Combination Therapy; Genetic Interactions; High-Density Transposon Mutagenesis; Systems Biology

The rapid rise in antibiotic resistance is accelerating our need to find new antibiotics with novel mechanisms of action. Current antibiotics target a limited number of bacterial processes that are performed by the product of essential genes. However, the

抗生素耐药性的迅速上升加速了我们寻找具有新作用机制的新抗生素的需求。目前的抗生素针对有限数量的细菌过程，这些过程由必需基因的产物进行。但