Bacteriology PhD Training Program

细菌学博士培养计划

• 批准号: 10158444
• 负责人: DAVID Z RUDNER
• 金额: $ 35.57万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158444
• 关键词: Bacteriology; Doctor of Philosophy; Training Programs

Project Summary/Abstract This application requests funding to support 8 second- and third-year graduate students in the Harvard Graduate Program in Bacteriology (GPiB). The goal of this program is to train highly skilled experimentalists firmly grounded in the logic and rigor of the scientific method and, from that base, empower them to identify and pursue the challenges and opportunities of modern bacteriology. The GPiB builds upon more than a half- century of successful research and training in bacteriology at Harvard Medical School (HMS) and the Harvard TH Chan School of Public Health (HSPH). At the heart of this inter-school program is a vibrant and supportive community of microbiologists that draws its strength from decades of scientific exchange, active collaborations, training successes, and long-standing friendships. The GPiB harnesses the camaraderie, mentorship, and infrastructure of this community and combines it with coursework, program-specific activities, and dissertation research. Trainees in the 22 program faculty labs investigate topics ranging from gene regulation and cell wall biogenesis to the molecular underpinnings of drug resistance and its spread through populations. Students enter the GPiB through the Biological and Biomedical Sciences (BBS) program at HMS or the Biological Sciences in Public Health (BPH) program at HSPH and are selected for the program based on their expressed interest in the GPiB during their first year of graduate school and their choice of dissertation laboratory.!The GPiB supplements the broad and successful training of the BBS and BPH umbrella programs with focused coursework in basic bacteriology, pathogenesis, and the host response. Two required bacteriology classes use primary literature to teach students to be critical readers and thinkers while developing skills in experimental design and communication. Additional training in quantitative methods is also required. Coursework and research are combined with career mentorship focused on transferrable skills including problem-solving, communication, and collaboration. The GPiB also provides a collection of resources and events that help trainees identify future career opportunities. Importantly, the success of our trainees and the program as a whole are not taken for granted. A novel set of surveys that monitor trainees and their mentors inform regular program assessments. The Harvard microbiology community is a diverse, passionate, and tight-knit group of scientists and the GPiB ensures that the rigor and commitment of this community will support the training of generations of successful bacteriologists.!

项目总结/摘要 此申请要求资助8名哈佛大学二年级和三年级的研究生 细菌学研究生课程（GPiB）。该计划的目标是培养高技能的实验人员 坚定地扎根于科学方法的逻辑和严谨性，并在此基础上，使他们能够识别 并追求现代细菌学的挑战和机遇。GPiB建立在超过一半的基础上- 哈佛医学院和哈佛医学院细菌学研究和培训的世纪 TH Chan School of Public Health（HSPH）在这个校际计划的核心是一个充满活力和支持 微生物学家的社区，从几十年的科学交流，积极的合作， 成功的训练和长久的友谊。GPiB利用了同志情谊，指导， 该社区的基础设施，并将其与课程作业，特定于计划的活动和论文相结合 research.在22个项目的教师实验室的实习生调查的主题，从基因调控和细胞壁 耐药性的分子基础及其在人群中的传播。学生 通过HMS的生物和生物医学科学（BBS）计划或生物学 科学在公共卫生（BPH）计划在HSPH，并根据他们的表达选择该计划 在研究生院的第一年对GPiB的兴趣和他们对论文实验室的选择。的 GPiB补充了BBS和BPH伞式计划的广泛和成功的培训， 基础细菌学、致病机理和宿主反应的课程。两个必需的细菌学课程使用 小学文学，教学生成为批判性的读者和思想家，同时发展技能，在实验 设计和沟通。还需要进行定量方法方面的额外培训。课程和 研究与职业指导相结合，重点是可转移的技能，包括解决问题， 沟通和协作。GPiB还提供了一系列资源和事件， 学员确定未来的职业机会。重要的是，我们的学员的成功和该计划作为一个 整体并不是理所当然的。一套新颖的调查，监测学员和他们的导师告知定期 方案评估。哈佛微生物学社区是一个多元化，充满激情和紧密团结的群体， 科学家和GPiB确保这个社区的严谨和承诺将支持培训 一代又一代成功的细菌学家

项目成果

To dismantle structural racism in science, scientists need to learn how it works.

为了消除科学中的结构性种族主义，科学家需要了解它是如何运作的。

• DOI: 10.1038/s41386-023-01534-2
• 发表时间: 2023
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Weinreb,Caleb;Sun,DaphneS
• 通讯作者: Sun,DaphneS

Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP.

• DOI: 10.1073/pnas.2210115119
• 发表时间: 2022-11-16
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.

• DOI: 10.1371/journal.ppat.1009063
• 发表时间: 2020-11
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Hicks ND;Giffen SR;Culviner PH;Chao MC;Dulberger CL;Liu Q;Stanley S;Brown J;Sixsmith J;Wolf ID;Fortune SM
• 通讯作者: Fortune SM

Analysis of multiple bacterial species and antibiotic classes reveals large variation in the association between seasonal antibiotic use and resistance.

• DOI: 10.1371/journal.pbio.3001579
• 发表时间: 2022-03
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Sun DS;Kissler SM;Kanjilal S;Olesen SW;Lipsitch M;Grad YH
• 通讯作者: Grad YH

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.

• DOI: 10.7554/elife.81856
• 发表时间: 2022-12-28
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Replogle, Joseph M.;Bonnar, Jessica L.;Pogson, Angela N.;Liem, Christina R.;Maier, Nolan K.;Ding, Yufang;Russell, Baylee J.;Wang, Xingren;Leng, Kun;Guna, Alina;Norman, Thomas M.;Pak, Ryan A.;Ramos, Daniel M.;Ward, Michael E.;Gilbert, Luke A.;Kampmann, Martin;Weissman, Jonathan S.;Jost, Marco
• 通讯作者: Jost, Marco