Mechanobiological adaptation in the craniofacial complex

颅面复合体的机械生物学适应

• 批准号: RGPIN-2021-03251
• 负责人: Zimmermann, Elizabeth
• 金额: $ 2.77万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=742454
• 关键词: Mechanobiological; adaptation; craniofacial; complex

Engineers often turn to nature for design inspiration. My research program investigates novel properties in the soft tissues surrounding bones that contribute to sensing mechanical deformation, damping physiological loads, as well as deformation- and direction-dependent permeability. Here, my investigations will focus on i) the periosteum - a fibrous sheath surrounding bones - and ii) the dentoalveolar joint - where the soft periodontal ligament (PDL) connects the tooth to the jaw bone. The long-term goals of this research program are to improve our fundamental knowledge surrounding the mechanobiology of mineralized tissues and to inspire the design of engineering materials with novel properties. As a first step towards these long-term goals, my research program will address the following three aims: Objective 1: Investigate the structure and mechanical behavior of the periosteum in relation to its role in bone adaptation and permeability characteristics. My hypothesis is that the periosteum will have a different structure (organization, morphology) and mechanical behavior at surfaces of active bone formation vs surfaces of inactive bone formation. Longer-term goal: Develop soft, transparent surface layers for engineering materials mimicking the sensing ability and permeability of the periosteum. Objective 2: Examine the multi-scale structure and mechanical behavior of the dentoalveolar joint in teeth with different functions. My hypothesis is that the multi-scale structure (morphology, microarchitecture, and material properties) of the dentoalveolar joint varies based on different functional patterns. Longer-term goal: Develop soft engineering joints with multi-scale design inspired by the dentoalveolar joint. Objective 3: Develop imaging protocols and analysis routines to quantify the complex morphology and microarchitecture of the craniofacial musculoskeletal system. My long-term hypothesis here is that functional loading patterns impact bone morphology and microarchitecture. Longer-term goal: Develop and validate computational models of the craniofacial musculoskeletal system.

工程师们经常从大自然中寻找设计灵感。我的研究项目研究骨骼周围软组织中的新特性，这些特性有助于感知机械变形、衰减生理载荷以及与变形和方向相关的通透性。在这里，我的研究将集中在i)骨膜--环绕骨骼的纤维鞘--以及ii)牙槽关节--软牙周韧带(PDL)将牙齿与颌骨连接起来。这项研究计划的长期目标是提高我们围绕矿化组织的机械生物学的基础知识，并启发具有新特性的工程材料的设计。作为迈向这些长期目标的第一步，我的研究计划将解决以下三个目标：目标1：研究骨膜的结构和力学行为与其在骨适应和渗透性特征中的作用。我的假设是，骨膜在活跃的骨形成表面和不活跃的骨形成表面具有不同的结构(组织、形态)和力学行为。长期目标：为工程材料开发柔软、透明的表层，模仿骨膜的传感能力和渗透性。目的：研究不同功能牙牙槽关节的多尺度结构和力学行为。我的假设是，牙槽关节的多尺度结构(形态、微结构和材料特性)根据不同的功能模式而不同。长期目标：以牙槽关节为灵感，开发多尺度设计的软性工程关节。目的：建立颅面肌骨骼系统的成像方案和分析程序，以量化颅面肌骨骼系统的复杂形态和微结构。我的长期假设是，功能性负荷模式会影响骨骼形态和微结构。长期目标：开发和验证颅面肌肉骨骼系统的计算模型。