Producing punicic acid in yeast and evaluating its application in reducing antibiotic use in poultry via synthetic biology and broiler trial

在酵母中生产石榴酸,并通过合成生物学和肉鸡试验评估其在减少家禽抗生素使用方面的应用

基本信息

  • 批准号:
    561166-2020
  • 负责人:
  • 金额:
    $ 4.34万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Alliance Grants
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The Canadian poultry industry is moving away from the use of antibiotic growth promoters (AGP) in the production of broiler chickens and turkeys. Alternative products to AGP are critical to maintaining a viable and profitable poultry production system and ensuring a safe and healthy food product for consumers. Recent studies have indicated that an edible conjugated fatty acid, punicic acid, has strong anti-bacterial and anti-inflammatory activity and thus could be a potential alternative to AGP. However, its major natural source (pomegranate seed oil) is approximately $25/kg (drum pricing), which makes it uneconomical for feeding broilers. The objectives of this project are to produce punicic acid in baker's yeast and evaluate its efficacy to promote broiler growth and performance. The project will develop novel products and processes that can contribute to the overall strategy to reduce AGP use in Canadian chicken production. Moreover, previous studies indicated supplementation of punicic acid in feed had the potential to increase the market value of poultry products. Furthermore, since punicic acid has other valuable applications in nutraceutical (e.g. anti-cancer components), cosmetic and oleo-chemistry (e.g. industrial oil and bio-polymer), high-quality punicic acid produced via fermentation will also benefit the biotechnology industry in Canada. Finally, the proposed research will provide a better understanding of the fundamental factors associated with the production of plant-sourced unusual fatty acids in industrial microorganisms and the use of unusual fatty acids as AGP alternatives in animal feeding.
加拿大家禽业正在停止在肉鸡和火鸡生产中使用抗生素生长促进剂(AGP)。AGP的替代产品对于维持一个可行和有利可图的家禽生产系统以及确保消费者获得安全和健康的食品至关重要。最近的研究表明,一种可食用的共轭脂肪酸,即番茄酸,具有很强的抗菌和抗炎活性,因此可能成为AGP的潜在替代品。然而,其主要天然来源(石榴籽油)约为25美元/公斤(滚筒定价),这使得饲养肉鸡不划算。本项目的目标是在面包师酵母中生产番茄酸,并评估其促进肉鸡生长和生产性能的效果。该项目将开发新的产品和工艺,为减少加拿大鸡肉生产中使用AGP的总体战略做出贡献。此外,以前的研究表明,在饲料中添加辛酸有可能增加家禽产品的市场价值。此外,由于番茄酸在营养食品(例如抗癌成分)、化妆品和油脂化学(例如工业油和生物聚合物)中还有其他有价值的应用,通过发酵生产的高质量番茄酸也将使加拿大的生物技术产业受益。最后,拟议的研究将更好地了解与在工业微生物中生产植物来源的特殊脂肪酸以及在动物饲养中使用特殊脂肪酸作为AGP替代品有关的基本因素。

项目成果

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相似海外基金

Producing punicic acid in yeast and evaluating its application in reducing antibiotic use in poultry via synthetic biology and broiler trial
在酵母中生产石榴酸,并通过合成生物学和肉鸡试验评估其在减少家禽抗生素使用方面的应用
  • 批准号:
    561166-2020
  • 财政年份:
    2021
  • 资助金额:
    $ 4.34万
  • 项目类别:
    Alliance Grants
The First Pomegranate Seed Oil-Containing Medical Food for Gut and Immune Health
第一种含有石榴籽油的用于肠道和免疫健康的医疗食品
  • 批准号:
    10010938
  • 财政年份:
    2020
  • 资助金额:
    $ 4.34万
  • 项目类别:
Effects of conjugated linolenic acids on lipid metabolism and immune functions in rats.
共轭亚麻酸对大鼠脂质代谢和免疫功能的影响。
  • 批准号:
    16580107
  • 财政年份:
    2004
  • 资助金额:
    $ 4.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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