Effect of a functional encapsulated multivitamin on immune and oxidative responses in broiler chickens subjected to environmental and pathogenic stressors

功能性胶囊复合维生素对环境和致病应激源下肉鸡免疫和氧​​化反应的影响

• 批准号: 571577-2021
• 负责人: Adewole, DeborahDI
• 金额: $ 3.88万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=743584
• 关键词: Effect; functional; encapsulated; multivitamin; immune

Commercial broiler chickens experience stressors from environmental conditions and pathogenic infections, which alter their well-being and challenge their immune system and antioxidant status, leading to high mortality, which results in significant economic losses to farmers. Developing approaches to mitigate these stressors is critical given the increased demand to raise chickens without preventive antibiotics. Several vitamins are potent antioxidants and coenzymes for crucial biological processes and thus present a successful strategy to combat management, environmental and pathogenic stresses. Traditionally, these vitamins are incorporated into broiler chickens' diets in free form which makes them prone to oxidation and heat damage during feed processing, thereby reducing their effectiveness in the gastrointestinal tract. Encapsulation technology protects and stabilizes oxidizable substrates to achieve targeted delivery and enhance their health-promoting effects. Therefore, encapsulated multivitamins promise to be an effective intervention strategy, with significant merits over the unprotected multivitamins that are currently used in the industry. Moreover, their ability to boost the immune and antioxidant statuses presents them as a suitable antibiotic alternative, which promises to help save the $1.4 billion that Canadian healthcare system spends annually on antibiotic resistance-related infections. We propose to use an encapsulated multivitamin supplement to mitigate the stress induced by temperature challenge, E. coli, and Eimeria spp. (which cost the global poultry industry over 18 billion US dollars annually). The project will employ an array of experimental, statistical, and analytical techniques thus offering outstanding opportunities for HQP training - 1 Ph.D. and 2 undergraduate students. Results will be directly transmitted into use through a partnership with Jefo Nutrition Incorporation - a big player in the poultry industry who works with poultry farmers, feed manufacturers, premix companies, leading research institutes, and universities in Canada to create products that improve animal performance and well-being, thus increasing farmers' profit and their subsequent contributions to the Canadian economy.

商业肉鸡经历来自环境条件和病原体感染的压力，这改变了它们的健康状况，挑战了它们的免疫系统和抗氧化状态，导致高死亡率，给农民造成重大经济损失。鉴于在没有预防性抗生素的情况下养鸡的需求增加，开发减轻这些压力源的方法至关重要。几种维生素是有效的抗氧化剂和辅酶的关键生物过程，因此提出了一个成功的战略，以打击管理，环境和病原体的压力。传统上，这些维生素以游离形式掺入肉鸡的饮食中，这使得它们在饲料加工过程中易于氧化和热损伤，从而降低它们在胃肠道中的有效性。封装技术保护和稳定可氧化的基质，以实现靶向递送并增强其促进健康的作用。因此，封装的多维生素有望成为一种有效的干预策略，与目前行业中使用的无保护的多维生素相比具有显着的优点。此外，它们增强免疫和抗氧化状态的能力使它们成为合适的抗生素替代品，这有望帮助节省加拿大医疗保健系统每年用于抗生素耐药性相关感染的14亿美元。我们建议使用胶囊复合维生素补充剂，以减轻由温度挑战，E。coli和艾美耳球虫属（Eimeria spp.）（这使全球家禽业每年损失超过180亿美元）。该项目将采用一系列实验，统计和分析技术，从而为HQP培训提供出色的机会- 1博士。和2名本科生。结果将通过与Jefo Nutrition Incorporation的合作直接投入使用，Jefo Nutrition Incorporation是家禽业的一家大型企业，与加拿大的家禽养殖户，饲料制造商，预混料公司，领先的研究机构和大学合作，创造改善动物性能和福祉的产品，从而增加农民的利润及其对加拿大经济的后续贡献。