Mechanisms underlying the acquisition, performance, and evolution of vocal communication
声音交流的习得、表现和进化的潜在机制
基本信息
- 批准号:RGPIN-2022-03747
- 负责人:
- 金额:$ 4.01万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Vocal communication is a diverse and evolutionary widespread form of communication. How this diversity is generated and regulated within and across species is a fundamental question in ethology, evolutionary biology, and neuroscience. My interdisciplinary research program integrates systems, molecular, and comparative neuroscience to reveal fundamental mechanisms underlying the acquisition, performance, and evolution of vocal communication. My research program focuses on songbirds like zebra finches because they, like humans, learn their vocalizations during development and possess discrete neural circuits for vocal learning and performance. In addition, vocal learning and performance in both songbirds and humans are regulated by neuromodulators like dopamine and norepinephrine, by biological predispositions, and by activity in neural circuitry that have evolved through convergent mechanisms. Over the next five years, my research program will investigate (i) neuromodulatory influences on vocal learning and performance, (ii) mechanisms underlying biological predispositions in vocal learning, and (iii) mechanisms of neural circuit evolution for vocal learning. For example, I will use immunocytochemical, neuropharmacological, and behavioral approaches to reveal how dopamine and norepinephrine in sensorimotor circuits regulate vocal learning and control. I will also reveal how learning biases and activity in sensorimotor circuitry contribute to the emergence of acoustic patterns that are prevalent among songbirds and humans. Finally, because direct projections from sensorimotor areas in the forebrain to hindbrain vocal centers are hypothesized to underlying the evolution of vocal learning across vertebrates, I will examine the neuroanatomical and molecular specializations for these direct projections using novel, high-throughput genetic barcoding and genomic techniques. Taken together, my research program will uncover fundamental mechanisms underlying the learning, performance, and evolution of communicative behaviors. My studies will reveal neural mechanisms that generate behavioral diversity as well as biological processes that are shared between humans and non-human animals. In addition to generating high impact research, my program will also train HQP in cutting-edge neuroscience, molecular, and analytical tools that will prepare them for successful careers in academia and industry.
声音传播是一种多样的、进化的、广泛的传播形式。这种多样性是如何在物种内部和物种之间产生和调节的,是行为学、进化生物学和神经科学中的一个基本问题。我的跨学科研究计划整合了系统,分子和比较神经科学,以揭示声乐交流的获取,表现和进化的基本机制。我的研究项目主要集中在像斑胸草雀这样的鸣禽身上,因为它们和人类一样,在发育过程中学习发声,并拥有用于发声学习和表演的离散神经回路。此外,鸣禽和人类的声音学习和表现都受到多巴胺和去甲肾上腺素等神经调节剂的调节,受到生物倾向的调节,以及通过收敛机制进化的神经回路活动的调节。在接下来的五年里,我的研究计划将调查(一)神经调节对声乐学习和表演的影响,(二)声乐学习的生物学倾向的机制,以及(三)声乐学习的神经回路进化机制。例如,我将使用免疫细胞化学,神经药理学和行为学方法来揭示感觉运动回路中的多巴胺和去甲肾上腺素如何调节声音学习和控制。我还将揭示学习偏见和感觉运动回路中的活动如何促成鸣禽和人类中普遍存在的声学模式的出现。最后,因为直接预测从感觉运动区在前脑到后脑发声中心假设为基础的进化,在脊椎动物的发声学习,我将研究神经解剖和分子专业化,这些直接预测使用新的,高通量的遗传条形码和基因组技术。总之,我的研究计划将揭示沟通行为的学习,表现和演变的基本机制。我的研究将揭示产生行为多样性的神经机制,以及人类和非人类动物之间共享的生物过程。除了产生高影响力的研究,我的计划还将培训HQP在尖端神经科学,分子和分析工具,这将为他们在学术界和工业界的成功职业生涯做好准备。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Sakata, Jon其他文献
Sakata, Jon的其他文献
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{{ truncateString('Sakata, Jon', 18)}}的其他基金
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2018
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2017
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integration of brain circuits for the control and plasticity of vocal communication signals
整合脑电路以控制声音通信信号并使其可塑性
- 批准号:
RGPIN-2016-05016 - 财政年份:2016
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
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