Studies of naturally evolved regeneration

自然进化再生的研究

基本信息

  • 批准号:
    RGPIN-2019-04682
  • 负责人:
  • 金额:
    $ 4.23万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The ability to regenerate damaged body parts following injury is a dramatic but poorly understood phenomenon. While some species of bony fish and salamanders are capable of replacing multiple tissue types, most other species cannot. One emerging exception is lizards. For more than 300 years it has been recognized that many lizards can naturally regenerate a replacement tail. Ongoing research by my NSERC-funded program has discovered evidence of an expanded regenerative repertoire in lizards. More specifically, we determined that the leopard gecko, a common pet trade lizard, constantly makes new neurons and cardiac muscle cells (cardiomyocytes), two cell types that are essentially irreplaceable in mammals. In addition, we discovered that geckos also heal wounds to the skin without scarring. These data provide us with exciting new insight into the mechanisms responsible for spontaneously restoring tissue structure and function across multiple organs. The long-term goal of my research program is to identify and understand the biological mechanisms that permit and promote the structural and functional replacement of damaged tissues. To achieve this goal, we study the diverse and naturally occurring regenerative abilities of lizards. Our short-term objectives are to determine the cellular mechanisms and functional consequences involved in regenerating three distinct organs: the heart, brain, and skin. We hypothesize that regeneration is a tissue/organ-specific process that emphasizes functional restoration over precise structural replication. This innovative research program is essential for addressing one of the most challenging questions in biology: why do some tissues, organs, and species regenerate while others do not. Comparative studies, such as those involving lizards, are the gold standard for regeneration research. Further, this program will allow us to probe the evolution and diversity of self-repair mechanisms. Beyond regenerative biology, this research provides important contributions to the fields of stem cell and developmental biology. We anticipate that leopard geckos are capable of regenerating portions of the heart, brain, and skin, and that these exceptional abilities will reveal an unexpected diversity of reparative mechanisms. Knowledge acquired during this research is critical for a more complete understanding of how tissues can be naturally rebuilt after injury. This research has obvious benefits for biologists and biomedical scientists, with important implications for translational medicine. We are global leaders in the field of reptile regeneration, with unique expertise in lizard biology, surgery, histology, and behavior. We have a proven track record of public engagement, scientific communication, and recruiting highly qualified personnel of diverse backgrounds. The originality and charisma of the leopard gecko model has proven successful in recruiting students and promoting public interest in science.
在受伤后再生受损身体部位的能力是一种引人注目但知之甚少的现象。虽然一些硬骨鱼和蝾螈能够替代多种组织类型,但大多数其他物种不能。一个新出现的例外是蜥蜴。300多年来,人们已经认识到许多蜥蜴可以自然地再生一条替代尾巴。我的NSERC资助的项目正在进行的研究发现了蜥蜴再生能力扩展的证据。更具体地说,我们确定豹壁虎,一种常见的宠物贸易蜥蜴,不断产生新的神经元和心肌细胞(心肌细胞),这两种细胞类型在哺乳动物中基本上是不可替代的。此外,我们还发现壁虎还能愈合皮肤伤口而不会留下疤痕。这些数据为我们提供了令人兴奋的新见解,了解了多个器官自发恢复组织结构和功能的机制。 我的研究计划的长期目标是识别和理解允许和促进受损组织的结构和功能替换的生物学机制。为了实现这一目标,我们研究蜥蜴的多样性和自然发生的再生能力。我们的短期目标是确定再生三个不同器官的细胞机制和功能后果:心脏,大脑和皮肤。我们假设再生是一个组织/器官特异性的过程,强调功能恢复精确的结构复制。 这项创新的研究计划对于解决生物学中最具挑战性的问题之一至关重要:为什么有些组织,器官和物种可以再生,而其他组织,器官和物种不能再生。比较研究,如涉及蜥蜴的研究,是再生研究的黄金标准。此外,该计划将使我们能够探索自我修复机制的进化和多样性。除了再生生物学,这项研究还为干细胞和发育生物学领域做出了重要贡献。 我们预计,豹壁虎能够再生心脏,大脑和皮肤的部分,这些特殊的能力将揭示一个意想不到的修复机制的多样性。在这项研究中获得的知识对于更全面地了解组织如何在受伤后自然重建至关重要。这项研究对生物学家和生物医学科学家有明显的好处,对转化医学有重要意义。我们是爬行动物再生领域的全球领导者,在蜥蜴生物学、外科学、组织学和行为学方面拥有独特的专业知识。我们在公众参与、科学交流和招聘不同背景的高素质人才方面有着良好的记录。豹壁虎模型的独创性和魅力已被证明成功地招募学生和促进公众对科学的兴趣。

项目成果

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Vickaryous, Matthew其他文献

A comparative histological study of the osteoderms in the lizards Heloderma suspectum (Squamata: Helodermatidae) and Varanus komodoensis (Squamata: Varanidae)
  • DOI:
    10.1111/joa.13156
  • 发表时间:
    2020-01-27
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Kirby, Alexander;Vickaryous, Matthew;Evans, Susan
  • 通讯作者:
    Evans, Susan

Vickaryous, Matthew的其他文献

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{{ truncateString('Vickaryous, Matthew', 18)}}的其他基金

Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2021
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPAS-2019-00006
  • 财政年份:
    2020
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2020
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPAS-2019-00006
  • 财政年份:
    2019
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2019
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of spontaneous regeneration in a novel amniote model
新型羊膜动物模型自发再生的研究
  • 批准号:
    RGPIN-2014-04676
  • 财政年份:
    2018
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of spontaneous regeneration in a novel amniote model
新型羊膜动物模型自发再生的研究
  • 批准号:
    RGPIN-2014-04676
  • 财政年份:
    2017
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of spontaneous regeneration in a novel amniote model
新型羊膜动物模型自发再生的研究
  • 批准号:
    RGPIN-2014-04676
  • 财政年份:
    2016
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of spontaneous regeneration in a novel amniote model
新型羊膜动物模型自发再生的研究
  • 批准号:
    RGPIN-2014-04676
  • 财政年份:
    2015
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of spontaneous regeneration in a novel amniote model
新型羊膜动物模型自发再生的研究
  • 批准号:
    RGPIN-2014-04676
  • 财政年份:
    2014
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2021
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPAS-2019-00006
  • 财政年份:
    2020
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2020
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
Using naturally evolved phenotypic variation to decipher the positional regulatory code of mammalian skin
利用自然进化的表型变异破译哺乳动物皮肤的位置调节密码
  • 批准号:
    10478147
  • 财政年份:
    2019
  • 资助金额:
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Naturally Evolved Cellular Adaptations to Anoxia
自然进化的细胞对缺氧的适应
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    2019
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    $ 4.23万
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    Discovery Grants Program - Individual
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自然进化再生的研究
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    RGPAS-2019-00006
  • 财政年份:
    2019
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
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利用自然进化的表型变异破译哺乳动物皮肤的位置调节密码
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    10246985
  • 财政年份:
    2019
  • 资助金额:
    $ 4.23万
  • 项目类别:
Studies of naturally evolved regeneration
自然进化再生的研究
  • 批准号:
    RGPIN-2019-04682
  • 财政年份:
    2019
  • 资助金额:
    $ 4.23万
  • 项目类别:
    Discovery Grants Program - Individual
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利用自然进化的表型变异破译哺乳动物皮肤的位置调节密码
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  • 财政年份:
    2019
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自然进化的细胞对缺氧的适应
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    RGPIN-2015-06588
  • 财政年份:
    2018
  • 资助金额:
    $ 4.23万
  • 项目类别:
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