Evaluation of the anticancer activity of a new autophagy-inhibitory drug

新型自噬抑制药物的抗癌活性评价

• 批准号: 194925
• 负责人: Roberge Michel
• 金额: $ 10.42万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2010-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=194925&lang=en
• 关键词: Autophagy; Breast Cancer; Cancer; In Vivo Evaluation; Lung Cancer; Xenograft

Several cancer drugs elicit a protective response called autophagy (self-eating) that enables cancer cells to survive exposure to the drug. It is anticipated that autophagy inhibitors will increase the efficacy of these drugs but few chemical inhibitors o

几种抗癌药物会引发一种称为自噬（自食）的保护性反应，使癌细胞能够在暴露于药物的情况下存活下来。预计自噬抑制剂将增加这些药物的疗效，但很少有化学抑制剂，