Nanoprecipitation for controlled formation of rasagaline mesylate (RM) microparticle agents

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Parkinson's disease is a neurodegeneration disorder, affecting 1 in every 500 people in Canada. Rasagiline mesylate (RM) is a drug for treatment of Parkinson's disease. As a hydrophilic compound, RM has a short elimination half-life. Currently the clinical applications of RM for Parkinson's disease treatment are limited by its low bioavailability and the requirement of daily administrations. The quick and 'burst' release profiles of RM make it challenging for drug delivery systems. Through the partnership with Hermay Labs Corporation, the overall goal of the project is to develop a technology for producing RM microparticle agents used in control release systems. The project will employ a nanoprecipitation-based approach for producing RM microparticle agents by using an antisolvent. The physicochemical characteristics (size distribution, loading and encapsulation efficiency) of the agents will be controlled by both mixture composition and mixing dynamics of the antisolvent. The solubility diagrams of multiple components will be constructed to guide the selection of composition ratios. A novel 2D mixing device will be used to determine the composition for desirable properties of the particles. The formation of RM particle agents will be induced in a wide range of mixing rate of the RM solution and the antisolvent with presence of carrier materials to tune the release profile of the RM agents. The potential outcomes of the project will be (1) effective protocols for producing RM microparticle agents by nanoprecipitation; (2) correlations between mixing conditions and the characteristics of RM microparticles; (3) improved understanding of nanoprecipitation for hydrophilic compound in general for clinic medications; (4) Patents, presentations in conferences, and publications in peer-viewed journals. Four HQPs will be trained on this 2-year project. The research activities supported by NSERC is crucial for success and long-term impact of the project.