Physical Properties and Colloidal Stability of Aluminium Hydroxide Adjuvants (RehydragelTM)

Chemtrade生产一系列用途广泛的铝基疫苗佐剂(AVA)，可用于各种pH值、蛋白质结合类型和其他疫苗要求。AVA生产过程中工艺参数的控制控制着其稳定性、流变性、颗粒大小等物理性质，影响其作为疫苗佐剂的效力。拟议的研究将集中于阐明AVA的表面特性与其作为疫苗佐剂的稳定性和有效性之间的关系。将被量化的关键性质是：(A)颗粒大小，(B)Zeta电位，(C)形貌，(D)流变学和(E)纳米颗粒的表面组成。我们将开发合成方案，以阐明控制雷海尔凝胶佐剂胶体稳定性的参数。此外，我们还将对生产批次的复水凝胶样品进行质量保证分析，以阐明工艺参数与AVA物理性能之间的关系。该项目的主要目标是发展对AVA的胶体化学的基本了解，并利用这些知识来促进和改进AVA的性能，即其长期稳定性和作为疫苗佐剂的效力。此外，我们将培训高素质人员，以支持更好的AVA的开发和生产，以支持人类和兽医应用对疫苗日益增长的需求。

Chemtrade produces an extensive line of highly versatile aluminum-based Vaccine Adjuvants (AVA) that can be used over a broad range of pH, types of protein binding, and other vaccine requirements. The control of the processing parameters in the production of AVA control their physical properties, such as stability, rheology, particle size, which have an impact on their efficacy as vaccine adjuvants. The proposed research will focus on elucidating the relationship between the surface characteristics of AVA on their stability and efficacy as vaccine adjuvants. The key properties that will be quantified are, (a) particle size, (b) zeta potential, (c) morphology, (d) rheology and (e) surface composition of the nanoparticles. We will develop synthetic protocols to elucidate the parameters that control the colloidal stability of the Rehydragel adjuvants. Additionally, we will conduct QA analyses of the Rehydragel samples from production batches in order to elucidate the relationship between processing parameters and the physical properties of the AVA. The key objective of the project is to develop fundamental understanding on the colloidal chemistry of the AVA, and to use this knowledge to advance and improve the performance of the AVA, in terms of their long-term stability and their efficacy as vaccine adjuvants. Additionally, we will train highly qualified personnels to support the development and production of better AVA to support the growing demands and needs of vaccine in human and veterinary applications.