Development of pH-responsive carriers for the controlled release of encapsulated acidifying and antibacterial agents

开发用于控制释放封装酸化剂和抗菌剂的 pH 响应载体

• 批准号: 531450-2018
• 负责人: Mauzeroll, JanineJ
• 金额: $ 4.07万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747530
• 关键词: Development; pH; responsive; carriers; controlled

With the ever-present specter of drug-resistant microbes and emerging infectious diseases looming large,establishing and maintaining stringent and up-to-date disinfection practices has taken on paramount importancein a growing number of industries. In addition to effectively neutralizing pathogens, novel disinfectantformulations must be, as much as possible, environmentally benign and nontoxic to individuals handling thesesubstances. In the sanitation field, chlorine has long found application as a straightforward broad-spectrumdisinfectant. However, certain microbes including Cryptosporidium - the most prevalent causative agent inrecreational water illnesses - are resistant to chlorine treatment. Addressing this issue requires either thedevelopment of novel disinfectants or refinement of the efficiency of existing approaches. To this end, wepropose to develop disinfectant formulations based on pH-sensitive liposomes. Liposomes (lipid bilayervesicles) are sustainable, inherently biocompatible structures that have found broad application in the deliveryof encapsulated compounds, including significantly increased efficiency in the delivery of antimicrobials tobacteria. Our system will comprise liposomes encapsulating quaternary ammonium and peracetic aciddisinfectants that will undergo destabilization and fusion with microbial cells following a change in pH. Withthe ability to be applied in the bulk solution or as a surface treatment, this novel disinfectant delivery systemwill represent a significant step forward in aligning disinfectant practices in the sanitation industry withcontemporary challenges.

随着耐药微生物和新兴传染病的幽灵不断出现，建立和保持严格和最新的消毒规范在越来越多的行业中具有至关重要的意义。除了有效地中和病原体之外，新型消毒剂配方必须尽可能地对环境友好，并且对处理这些物质的个人无毒。在卫生领域，氯作为一种直接的广谱消毒剂早已被应用。然而，某些微生物，包括隐孢子虫-最普遍的病原体在娱乐用水疾病-是耐氯处理。解决这个问题需要开发新的消毒剂或改进现有方法的效率。为此，我们建议开发基于pH敏感脂质体的消毒剂制剂。脂质体（脂质双层囊泡）是可持续的、固有的生物相容性结构，其在递送包封的化合物中具有广泛的应用，包括显著提高抗菌剂对细菌的递送效率。我们的系统将包括脂质体封装的季铵和过氧乙酸消毒剂，将经历不稳定和融合的微生物细胞后，在pH值的变化。与能力被应用在散装溶液或作为表面处理，这种新型的消毒剂输送系统将代表一个重要的一步，在卫生行业与当代挑战的消毒剂的做法。