Development of pH-responsive carriers for the controlled release of encapsulated acidifying and antibacterial agents.

随着抗药性微生物和新出现的传染病的幽灵不断出现， 建立和保持严格和最新的消毒方法至关重要 在越来越多的行业中。除了有效地中和病原体，新型消毒剂 制剂必须尽可能地对处理这些制剂的个人是环境友好和无毒的。 物质.在卫生领域，氯作为一种直接的广谱消毒剂， 消毒剂然而，某些微生物，包括隐孢子虫-最普遍的病原体， 娱乐用水疾病-对氯处理有抵抗力。解决这个问题需要 开发新的消毒剂或改进现有方法的效率。为此我们 建议开发基于pH敏感脂质体的消毒剂制剂。脂质体（脂质双层 囊泡）是可持续的、固有的生物相容性结构， 包封化合物，包括显着提高抗菌剂的输送效率， 细菌我们的系统将包括脂质体封装季铵和过氧乙酸 在pH值变化后将经历去稳定化并与微生物细胞融合的消毒剂。 能够应用于本体溶液或作为表面处理，这种新型消毒剂输送系统 将代表着在卫生行业的消毒剂实践中迈出的重要一步， 当代挑战。

With the ever-present specter of drug-resistant microbes and emerging infectious diseases looming large, establishing and maintaining stringent and up-to-date disinfection practices has taken on paramount importance in a growing number of industries. In addition to effectively neutralizing pathogens, novel disinfectant formulations must be, as much as possible, environmentally benign and nontoxic to individuals handling these substances. In the sanitation field, chlorine has long found application as a straightforward broad-spectrum disinfectant. However, certain microbes including Cryptosporidium - the most prevalent causative agent in recreational water illnesses - are resistant to chlorine treatment. Addressing this issue requires either the development of novel disinfectants or refinement of the efficiency of existing approaches. To this end, we propose to develop disinfectant formulations based on pH-sensitive liposomes. Liposomes (lipid bilayer vesicles) are sustainable, inherently biocompatible structures that have found broad application in the delivery of encapsulated compounds, including significantly increased efficiency in the delivery of antimicrobials to bacteria. Our system will comprise liposomes encapsulating quaternary ammonium and peracetic acid disinfectants that will undergo destabilization and fusion with microbial cells following a change in pH. With the ability to be applied in the bulk solution or as a surface treatment, this novel disinfectant delivery system will represent a significant step forward in aligning disinfectant practices in the sanitation industry with contemporary challenges.