A molecular-level basis for the development of new herbicides

开发新型除草剂的分子水平基础

• 批准号: 576811-2022
• 负责人: Palmer, DavidDRJ
• 金额: $ 2.78万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747586
• 关键词: molecular; level; basis; development; new

Plants make an essential amino acid, lysine, by a pathway of biochemical steps that build lysine from simpler starting compounds. These steps are catalyzed by proteins called enzymes, and compounds that can inhibit such enzymes could be used as herbicides. To develop safe and selective herbicides, a detailed understanding of the interactions of such compounds with enzymes of interest are necessary. This project aims to explore the mechanism of action of one such compound on a purified plant enzyme target, including high-resolution structural information, leading to the development of new and more effective herbicides that can help reduce the cost of crop production and/or increase crop yield, helping Canadian crop producers and consumers. The results will also improve our understanding of protein binding of small molecules.

植物通过一系列生化步骤从更简单的起始化合物中合成赖氨酸，从而制造出一种必不可少的氨基酸--赖氨酸。这些步骤是由一种名为酶的蛋白质催化的，能够抑制这种酶的化合物可以用作除草剂。为了开发安全和选择性的除草剂，有必要详细了解这些化合物与感兴趣的酶的相互作用。该项目旨在探索一种这样的化合物对纯化的植物酶靶标的作用机制，包括高分辨率结构信息，导致开发新的和更有效的除草剂，有助于降低作物生产成本和/或提高作物产量，帮助加拿大作物生产者和消费者。这一结果也将提高我们对蛋白质与小分子结合的理解。