Design of New Catalysts and Reagents for Site-Selective Reaction of C-H Bonds
C-H键位点选择性反应新型催化剂和试剂的设计
基本信息
- 批准号:RGPIN-2019-06290
- 负责人:
- 金额:$ 2.48万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Organic molecules are typically encased in a layer of carbon-hydrogen (C-H) bonds that are relatively strong and unreactive. There are chemical processes that have the ability to break these bonds and make new bonds between carbon and other elements. However, it is challenging to control such reactions so only a single one of these stable C-H bonds is broken. While there has been good progress using many parallel approaches many, if not most, C-H bonds cannot be broken in a predictable and targeted way. If we had such an ability, it would transform the creation of new organic molecules. From pharmaceuticals and biological probes to polymers and printed electronics, every field of science that requires custom-made organic molecules could benefit from technology such as this. In this proposal, we have identified new strategies that make it possible to predictably react several particular kinds of C-H bonds that were difficult or impossible to selectively target before. We envision that end users ranging from materials scientists working in industry to medical researchers working in academia will benefit from the tools we will provide. Our expertise and focus is in new catalyst development. To maximize the impact of the resources provided to us, we will use established techniques of machine learning. This will provide a breadth of skills to highly qualified personnel that will go on to contribute to Canadian society in whatever future paths they choose.
有机分子通常被包裹在碳-氢(C-H)键的一层中,这些键相对较强,不起作用。有一些化学过程有能力打破这些键,并在碳和其他元素之间形成新的键。然而,控制这样的反应是具有挑战性的,因此只有一个稳定的C-H键被破坏。尽管使用了许多平行的方法取得了良好的进展,但许多(如果不是大多数)C-H键无法以可预测和有针对性的方式打破。如果我们有这样的能力,它将改变新有机分子的创造。从制药和生物探针到聚合物和印刷电子产品,每一个需要定制有机分子的科学领域都可以从这样的技术中受益。在这项提议中,我们确定了新的策略,使得有可能对几种以前很难或不可能选择性靶向的特定类型的C-H键进行可预测的反应。我们预计,从在工业中工作的材料科学家到在学术界工作的医学研究人员,最终用户将从我们将提供的工具中受益。我们的专长和重点是新型催化剂的开发。为了最大限度地发挥提供给我们的资源的影响,我们将使用现有的机器学习技术。这将为高素质的人员提供广泛的技能,这些人员将继续在他们选择的未来道路上为加拿大社会做出贡献。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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VanHumbeck, Jeffrey其他文献
VanHumbeck, Jeffrey的其他文献
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{{ truncateString('VanHumbeck, Jeffrey', 18)}}的其他基金
Design of New Catalysts and Reagents for Site-Selective Reaction of C-H Bonds
C-H键位点选择性反应新型催化剂和试剂的设计
- 批准号:
RGPIN-2019-06290 - 财政年份:2021
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Design of New Catalysts and Reagents for Site-Selective Reaction of C-H Bonds
C-H键位点选择性反应新型催化剂和试剂的设计
- 批准号:
RGPIN-2019-06290 - 财政年份:2020
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Design of New Catalysts and Reagents for Site-Selective Reaction of C-H Bonds
C-H键位点选择性反应新型催化剂和试剂的设计
- 批准号:
DGECR-2019-00477 - 财政年份:2019
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Launch Supplement
Design of New Catalysts and Reagents for Site-Selective Reaction of C-H Bonds
C-H键位点选择性反应新型催化剂和试剂的设计
- 批准号:
RGPIN-2019-06290 - 财政年份:2019
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Organocatalytic Chemistry: Cascade Diamination Approach to Tamiflu
有机催化化学:达菲的级联二胺化方法
- 批准号:
358516-2008 - 财政年份:2010
- 资助金额:
$ 2.48万 - 项目类别:
Postgraduate Scholarships - Doctoral
Organocatalytic Chemistry: Cascade Diamination Approach to Tamiflu
有机催化化学:达菲的级联二胺化方法
- 批准号:
358516-2008 - 财政年份:2009
- 资助金额:
$ 2.48万 - 项目类别:
Postgraduate Scholarships - Doctoral
Organocatalytic Chemistry: Cascade Diamination Approach to Tamiflu
有机催化化学:达菲的级联二胺化方法
- 批准号:
358516-2008 - 财政年份:2008
- 资助金额:
$ 2.48万 - 项目类别:
Postgraduate Scholarships - Doctoral
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RGPIN-2019-06290 - 财政年份:2020
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
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C-H键位点选择性反应新型催化剂和试剂的设计
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Discovery Launch Supplement
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